Identification of anticancer potential compounds and its in silico prediction of the cytotoxic activity in majapahit (Crescentia cujete L.) stem bark

Fatimah, Fatimah; Martha, Rahma Diyan; Danar, Danar; Zummah, Atiqoh; Anggraini, Ines Marisya Dwi; Kusumawati, Asmarani

doi:10.1063/5.0112833

Cited by 1 publication

(1 citation statement)

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“…Compounds in the extract were identified using LCMS (Shimadzu LCMS-8040 LC/MS), which provided information about their structure [6]. Previous studies have been conducted on various parts of the Majapahit plant, including toxicity analysis and anticancer potential of the leaves using maceration with methanol solvent of BSLT [7], identification of potential anticancer compounds and in silico prediction on the stem bark [8], as well as detection and identification of flavonoid compounds in the ethanol extract of the bark using LCMS [9]. The novelty of this study is predicated on the identification and classification of flavonoid compounds, which are secondary metabolites in the ethanol extract of Majapahit plant leaves.…”

Section: Introductionmentioning

confidence: 99%

Identification of Flavonoid Compounds in Ethanol Extract of Majapahit plant (Crescentia cujete) Leaves and their Potential as Anticancer

Martha,

Fatimah,

Danar

et al. 2023

CHEESA

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<p>The Majapahit plant is commonly found in Indonesia but is rarely used due to a lack of information about its potential. One of the secondary metabolites commonly found in this plant are flavonoids. Therefore, this study aims to determine the distribution of flavonoid compounds in the Majapahit plant, particularly their potential as anticancer activty. Leaf material from Majapahit plants was extracted using the maceration technique, while the flavonoid compounds in the extract were identified using LCMS (Shimadzu LCMS-8040 LC/MS). The identification results showed that about 97 compounds were detected, including 14 flavonoids. The flavonoid compounds found include Quercetin, Chlorogenic acid, Kaempferol 3-O rhamnoside, Acacetin 7-rutinoside, Fortunellin, Kaempferol 3-[6”-(3-hydroxy-3-methyl glutarl) glucoside], Didymin, Diosmin, Hesperidin, Rutin, Citrusoside C, Citrusoside D, Narirutin 4'-glucoside, and Kaempferol 3-[6”-(3-hydroxy-3-methylglutaryl)glucoside] -7-glucoside. The highest composition of the identified flavonoid compounds was found in Kaempferol 3-O rhamnoside, with a 3.90%</p>

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Section: Introductionmentioning

confidence: 99%