Identification of Antibiotics as Emerging Contaminants and Antimicrobial Resistance in Aquatic Environment of the Arges-Vedea, Buzau-Ialomita, Dobrogea-Litoral River Basins in Romania

Ilie, Mihaela; Deák, György; Marinescu, Florica; Ghita, Gina; Tociu, Carmen; Matei, Mihaela; Savin, Ioana; Boboc, Madalina; Raischi, Marius; Arsene, Miruna

doi:10.1007/978-981-16-7920-9_47

Cited by 2 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Estimates of the burden of AMR are very impressive with a total of 671,689 cases of infections with selected antibiotic -resistant bacteria occurring in 2015 in Europe, out of which 63.5% were associated with healthcare [13]. There are numerous studies identifying specific genes or resistant bacteria in the environment and highlighting the role of the aquatic environment in dissemination and emergence of antibiotic resistance [14,15,16]. Still, little is known about the transmission dynamics of resistant bacteria and resistance genes in aquatic environments.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Ecological Risk and the Development of Antimicrobial Resistance due to the Presence of the Macrolide Antibiotics Azithromycin and Clarithromycin in Romanian Aquatic Environment

Ilie,

Marinescu,

Ghita

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

The presence of antibiotics in the aquatic environment can result in the emergence of antibiotic-resistant pathogens. In this paper, our aim was to identify, quantify and distribute macrolide antibiotics in the aquatic environment in the river basins of Arges-Vedea, Buzau-Ialomita and Dobrogea-Litoral and of the Danube River. In the Arges-Vedea river basin area, clarithromycin was detected most frequently, i.e. 58.62%, in the Buzau-Ialomita river basin area with a frequency of 92.31% azithromycin was detected, and in the Dobrogea - Litoral river basin area clarithromycin was detected with a frequency of 35.48%. The highest concentration of azithromycin, 559 ng/L and of clarithromycin, 502 ng/L was recorded in the Buzau-Ialomita river basin. The ecotoxicological RQecotox risk was also estimated, as well as the risk of developing antibiotic resistance of RQAMR pathogens, by the ratio of Measured Environmental Concentration (MEC) and Predicted No Effect Concentrations (PNEC). The study also aimed to investigate the prevalence of antibiotic resistance in potentially pathogenic bacteria isolated from aquatic environments. Thus, for β-lactam antibiotics, E. coli strains isolated from the Danube River exhibited a very high level of resistance to ampicillin (51%) and high level to azithromycin (43%), cefazolin (38%), amoxicillin+clavulanic acid (36%) and cefoxitin (26%). Low and respectively, low level resistance was noticed for aztreonam (6%) and imipenem (4%).

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of the Ecological Risk and the Development of Antimicrobial Resistance due to the Presence of the Macrolide Antibiotics Azithromycin and Clarithromycin in Romanian Aquatic Environment

Ilie,

Marinescu,

Ghita

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…As noted by the European Commission [1] and UNESCO [2] there are limited databases on the consumption of pharmaceuticals, their concentrations in environment and emissions from various sources. The potential risk associated with emerging pharmaceutical compounds to aquatic ecosystems has been noted in various scientific research papers [3,4,5,6,7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Investigations Regarding The Contamination with Emerging Pharmaceutical Pollutants in Representative Rivers and Lakes in Romania

Ghita,

Ilie,

Tudor

et al. 2023

E3S Web Conf.

Self Cite

View full text Add to dashboard Cite

The presence of emerging pharmaceutical pollutants in the aquatic environment is generally related to anthropogenic activities such as domestic, industrial and hospital wastewater discharges and landfills. Special attention should be paid to the contamination of surface waters, as they are partly used for drinking water supply, since they directly collect partly untreated wastewater from wastewater treatment plant. Within this paper, the identification, quantification and distribution of pharmaceutical micropollutants, from different complex environmental matrices, respectively: surface water, sediment and biota in the river basins of Arges-Vedea, Buzau-Ialomita and Dobrogea-Litoral and of the Danube River, were achieved. Also, preliminary investigations were carried out regarding the contamination of lakes with active pharmaceutical ingredients (APIs) the metropolitan area of the municipality of Bucharest. Among the pharmaceutical micropollutants identified in the Arges-Vedea river basin, the most frequently detected was paracetamol with a frequency of 69% and antibiotics with a frequency of 65.52%, in the Dobrogea-Litoral basin paracetamol was detected with a frequency of 74.2% and antibiotics with a frequency of 54.84%, while antibiotics were identified in all surface water samples and paracetamol with a frequency of 80% in the Buzau-Ialomita river basin. Considering the contamination of sediments with pharmaceutical residues, these were identified in all studied areas and in biota samples (fish) up to 18.21 ng/g were detected. The preliminary identification of active pharmaceutical ingredients (APIs) from Lakes Plumbuita, Carol, Morii, Alexandru Ioan Cuza (IOR), Herastrau and Tei indicated the frequent presence of several items, such as paracetamol, tinidazole, carbamazepine, moxifloxacin, clarithromycin, and caffeine.

show abstract

Identification of Antibiotics as Emerging Contaminants and Antimicrobial Resistance in Aquatic Environment of the Arges-Vedea, Buzau-Ialomita, Dobrogea-Litoral River Basins in Romania

Cited by 2 publications

References 16 publications

Evaluation of the Ecological Risk and the Development of Antimicrobial Resistance due to the Presence of the Macrolide Antibiotics Azithromycin and Clarithromycin in Romanian Aquatic Environment

Evaluation of the Ecological Risk and the Development of Antimicrobial Resistance due to the Presence of the Macrolide Antibiotics Azithromycin and Clarithromycin in Romanian Aquatic Environment

Investigations Regarding The Contamination with Emerging Pharmaceutical Pollutants in Representative Rivers and Lakes in Romania

Contact Info

Product

Resources

About