Identification of anti-idiotypic antibodies in the sera of ryegrass-allergic and nonallergic individuals

Valacer, David J.; O'Reilly, Mary Ellen; Ilowite, Norman T.; Bonagura, Vincent R.

doi:10.1016/0091-6749(91)90096-7

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…Anti‐idiotypic antibodies directed against idiotypes carried by allergen‐specific IgG and IgE in atopic and non‐atopic individuals have been reported [ 26–28]. The presence of IgG‐Fel d 1 only after the induction of IC with cat allergen suggests that at least in that sample the Fel d 1 antigenic activity did not correspond to an anti‐idiotypic IgG antibody.…”

Section: Discussionmentioning

confidence: 99%

Circulating cat allergen and immune complexes in cat‐ allergic children

Casas

Djerf

Häggström

et al. 1998

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Circulating cat allergen and immune complexes in cat‐ allergic children

Casas

Djerf

Häggström

et al. 1998

Clin Experimental Allergy

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“…Strikingly, this effect could be achieved although no allergen-specific IgG or IgE could be detected in the sera of the healthy donors. The authors discussed that anti-ids in healthy persons could regulate the IgE response by suppressor mechanisms 25. Indeed, a dramatic suppressive effect of anti-ids on the IgE response was observed in experimental studies.…”

Section: The Functional Role Of Anti-ids In Allergymentioning

confidence: 99%

Anti-Ids in Allergy: Timeliness of a Classic Concept

Wallmann

Pali‐Schöll

Jensen‐Jarolim

2010

World Allergy Organization Journal

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Abstract:Anti-idiotypic antibodies (anti-ids) are part of natural immune responses with regulatory capacity. Their effect on an antigen-specific, so-called Ab1 antibody response, is dependent on 1) the original antigen, which they mirror, being Ab2 antibodies, and 2) their isotype. In the case of IgE-mediated allergy, natural anti-ids against allergen-specific IgE represent internal images of allergen molecules. A key biologic feature of allergens is that they can crosslink IgE, expressed by B-lymphocytes or passively bound via high affinity receptors to effector cells, which renders cellular activation. Therefore, the IgE cross linking capability of anti-ids determines whether they dampen or enhance immediate-type hypersensitivity. Correspondingly to classic antiallergen blocking IgG antibodies, anti-ids may also interact with inhibitory FcγRIIb receptors and, thereby, down-regulate TH2-type inflammation. Anti-ids and other B-cell epitope mimetics, like mimotopes and DARPins, represent antigen surrogates, which can be used for vaccination. Intriguingly, they may induce antibody responses without activating potentially proinflammatory, antiallergen T-lymphocytes. Taken together, collective evidence suggests that anti-ids, although representing immunologic classics, are a timeless concept in allergology.

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Human anti‐IgE antibodies by repertoire cloning

et al. 1994

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Anti-IgE antibodies have been detected in sera of patients with an allergic disease where they might play a role in the regulation of (Ig)E-mediated reactions. Using a recombinant phage surface display expression system a combinatorial library of antibody heavy and light chains was constructed from peripheral blood mononuclear cells from an atopic donor immunized with tetanus toxoid. Screening of the library allowed the identification of a large number of phages displaying human monovalent antigen-binding fragments (Phab) against tetanus toxoid and IgE. Surprisingly, we found a high frequency of Phab against particular IgE myelomas that was comparable to the frequency found for Phab against tetanus toxoid. However, most of these Phab were directed to different idiotypic determinants, depending on the IgE myeloma used for the panning procedure. Nevertheless, two clones were found to have anti-isotypic specificity and were shown to react specifically with the CH2 domain of the IgE heavy chain.

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Identification of anti-idiotypic antibodies in the sera of ryegrass-allergic and nonallergic individuals

Cited by 10 publications

References 12 publications

Circulating cat allergen and immune complexes in cat‐ allergic children

Circulating cat allergen and immune complexes in cat‐ allergic children

Anti-Ids in Allergy: Timeliness of a Classic Concept

Human anti‐IgE antibodies by repertoire cloning

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