Identification of Anoikis-Related Prognostic Genes and Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Single-Cell and Bulk Transcriptomic Analysis
Xiaowei Tang,
Xueqin Zhou,
Shu Huang
et al.
Abstract:Background
Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related deaths worldwide, posing a serious threat to human health and life. Extensive research into cell death mechanisms has revealed a link between anoikis and the development and progression of HCC. However, the specific mechanisms remain unclear.
Methods
We used AddModuleScore, single-sample gene set enrichment analysis (ssGSEA), and weighted gene co-expression network analysis (WGCNA) to identify anoikis-related genes at… Show more
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