Identification of androgen-regulated genes in human prostate

Vaarala, Markku H.; Hirvikoski, Pasi; Kauppila, Saila; Paavonen, Timo

doi:10.3892/mmr.2012.956

Cited by 46 publications

(41 citation statements)

References 23 publications

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“…This is in good concordance with our previous study on cranberry effects in men with non-bacterial prostatitis 14 . The down-regulation of serum PSA may be related a trend to down-regulation of beta-microseminoprotein (MSMB) which has been reported to be androgen regulated [18][19][20] . Unexpectedly, there was enhanced expression of PCA3 in the cranberry arm.…”

Section: Discussionmentioning

confidence: 99%

Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings

Študent¹,

Vidlář²,

Bouchal³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background and Objectives. Recently, we described an inverse association between cranberry supplementation and serum prostate specific antigen (PSA) in patients with negative biopsy for prostate cancer (PCa) and chronic nonbacterial prostatitis. This double blind placebo controlled study evaluates the effects of cranberry consumption on PSA values and other markers in men with PCa before radical prostatectomy. Methods. Prior to surgery, 64 patients with prostate cancer were randomized to a cranberry or placebo group. The cranberry group (n=32) received a mean 30 days of 1500 mg cranberry fruit powder. The control group (n=32) took a similar amount of placebo. Selected blood/urine markers as well as free and total phenolics in urine were measured at baseline and on the day of surgery in both groups. Prostate tissue markers were evaluated after surgery. Results. The serum PSA significantly decreased by 22.5% in the cranberry arm (n=31, P<0.05). A trend to down-regulation of urinary beta-microseminoprotein (MSMB) and serum gamma-glutamyltranspeptidase, as well as upregulation of IGF-1 was found after cranberry supplementation. There were no changes in prostate tissue markers or, composition and concentration of phenolics in urine. Conclusions. Daily consumption of a powdered cranberry fruit lowered serum PSA in patients with prostate cancer. The whole fruit contains constituents that may regulate the expression of androgen-responsive genes.

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Section: Discussionmentioning

confidence: 99%

Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings

Študent¹,

Vidlář²,

Bouchal³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Seven genes (including ASPN and Sox9 transcription factor) were consistently up-regulated by androgen at all three time points. On the other hand, ASPN mRNA (together with gremlin 1) was up-regulated in both benign prostate and cancer, three days after castration 43 . Similarly, ASPN (along with decorin and lumican) was up-regulated following aromatase inhibitor treatment in primary breast cancer 44 .…”

Section: Asporin Expression and Its Regulation In Normal Tissues And mentioning

confidence: 97%

Glycoprotein asporin as a novel player in tumour microenvironment and cancer progression

Simkova¹,

Kharaishvili²,

Slabáková³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Small leucine rich proteoglycans (SLRPs), major non-collagen components of the extracellular matrix (ECM), have multiple biological roles with diverse effects. Asporin, a member of the SLRPs class I, competes with other molecules in binding to collagen and affects its mineralization. Its role in cancer is only now being elucidated. Methods. The PubMed online database was used to search relevant reviews and original articles. Furthermore, altered asporin expression was analysed in publicly available genome-wide expression data at the Gene Expression Omnibus database. Results. Polymorphisms in the N-terminal polyaspartate domain, which binds calcium, are associated with osteoarthritis and prostate cancer. Asporin also promotes the progression of scirrhous gastric cancer where it is required for coordinated invasion by cancer associated fibroblasts and cancer cells. Besides the enhanced expression of asporin observed in multiple cancer types, such as breast, prostate, gastric, pancreas and colon cancer, tumour suppressive effects of asporin were described in triple-negative breast cancer. We also discuss a number of factors modulating asporin expression in different cell types relevant for alterations toing the tumour microenvironment. Conclusion. The apparent contradicting tumour promoting and suppressive effects of asporin require further investigation. Deciphering the role of asporin and other SLRPs in tumour-stroma interactions is needed for a better understanding of cancer progression and potentially also for novel tumour microenvironment based therapies.

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“…Because not all AGR3-expressing organs contain multiciliated cells, AGR3 likely has other functions in these organs. Further studies are required to determine whether AGR3 regulates ciliary function in cells outside the lung, identify functions for AGR3 in nonciliated cells, and analyze the significance of increased AGR3 expression in certain cancers, including liver (31), prostate (32), and breast (15) cancer. Unlike AGR2 and several other PDI family members, AGR3 is not induced during ER stress responses.…”

Section: Original Research Discussionmentioning

confidence: 99%

The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway

Bonser¹,

Schroeder²,

Ostrin

et al. 2015

Am J Respir Cell Mol Biol

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Protein disulfide isomerase (PDI) family members regulate protein folding and calcium homeostasis in the endoplasmic reticulum (ER). The PDI family member anterior gradient (AGR) 3 is expressed in the airway, but the localization, regulation, and function of AGR3 are poorly understood. Here we report that AGR3, unlike its closest homolog AGR2, is restricted to ciliated cells in the airway epithelium and is not induced by ER stress. Mice lacking AGR3 are viable and develop ciliated cells with normal-appearing cilia. However, ciliary beat frequency was lower in airways from AGR3-deficient mice compared with control mice (20% lower in the absence of stimulation and 35% lower after ATP stimulation). AGR3 deficiency had no detectable effects on ciliary beat frequency (CBF) when airways were perfused with a calcium-free solution, suggesting that AGR3 is required for calcium-mediated regulation of ciliary function. Decreased CBF was associated with impaired mucociliary clearance in AGR3-deficient airways. We conclude that AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway.

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Identification of androgen-regulated genes in human prostate

Cited by 46 publications

References 23 publications

Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings

Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings

Glycoprotein asporin as a novel player in tumour microenvironment and cancer progression

The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway

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