Identification of an N-acetylcysteine conjugate in the urine after oral administration of 2,4-dichloro-1-nitrobenzene to rats

Carcinogenicity and chronic toxicity of 2,4-dichloro-1-nitrobenzene (2,4-DCNB) were examined by dietary administration to F344/DuCrj rats and Crj:BDF(1) mice of both sexes for 2 years. Dietary administration commenced when the animals were 6 weeks old. The dietary concentration of 2,4-DCNB was 0 (control), 750, 1,500 and 3,000 ppm (w/w) for male and female rats; 0, 750, 1,500 and 3,000 ppm for male mice; and 0, 1,500, 3,000 and 6,000 ppm for female mice. In rats, there was a dose-dependent and significant induction of renal cell adenomas and carcinomas in both sexes and of preputial glands adenomas in males. In all the 2,4-DCNB-fed groups of both sexes, the incidence of atypical tubular hyperplasia, a pre-neoplastic lesion in the kidney, in the proximal tubule was significantly increased. In mice, there was a dose-dependent and significant induction of hepatocellular adenomas, hepatocellular carcinomas, hepatoblastomas and peritoneal hemangiosarcomas in both sexes. The incidence of acidophilic hepatocellular foci was also significantly increased in female mice. Thus, clear evidence of carcinogenic activity of 2,4-DCNB by 2-year feeding was demonstrated in both rats and mice.

show abstract

2,4-Dichloro-1-nitrobenzene exerts carcinogenicities in both rats and mice by two years feeding

Kano

Suzuki

Senoh

et al. 2012

Arch Toxicol

View full text Add to dashboard Cite

show abstract

Donor substrate specificity of bovine kidney gamma-glutamyltransferase

Agblor

Josephy

2013

Chemico-Biological Interactions

View full text Add to dashboard Cite

Mammalian γ-glutamyltransferase (GGT) is a glycoprotein consisting of two subunits -a light chain and a heavy chain. The light chain contains the catalytic activity; the heavy chain anchors the protein to the membrane. GGT catalyzes the hydrolysis of the γ-glutamyl isopeptide bond of glutathione conjugates, releasing glutamic acid, or the transfer of the γ-glutamyl group to an acceptor substrate. The specificity of the enzyme for xenobiotic donor substrates has not been

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Identification of an N-acetylcysteine conjugate in the urine after oral administration of 2,4-dichloro-1-nitrobenzene to rats

Cited by 2 publications

References 9 publications

2,4-Dichloro-1-nitrobenzene exerts carcinogenicities in both rats and mice by two years feeding

2,4-Dichloro-1-nitrobenzene exerts carcinogenicities in both rats and mice by two years feeding

Donor substrate specificity of bovine kidney gamma-glutamyltransferase

Contact Info

Product

Resources

About