Identification of an Increased Short-Term Blood Pressure Variability on Ambulatory Blood Pressure Monitoring as a Coronary Risk Factor in Diabetic Hypertensives

Ozawa, Motoko; Tamura, Kouichi; Okano, Yasuko; Matsushita, Kanehiro; Yanagi, Mai; Tsurumi‐Ikeya, Yuko; Oshikawa, Jin; Hashimoto, Tatsuo; Masuda, Shinichiro; Wakui, Hiromichi; Shigenaga, Atsu-ichiro; Azuma, Kouichi; Ishigami, Tomoaki; Toya, Yoshiyuki; Ishikawa, Toshiyuki; Umemura, Satoshi

doi:10.1080/10641960902822518

Cited by 33 publications

(27 citation statements)

References 34 publications

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“…19 Conversely, a few studies do demonstrate the positive correlation of diastolic BPV with adverse cardiovascular events in the literature. 17,20 In our study, 24-hour diastolic BPV was significantly higher in AAD patients. However, we did not find a positive correlation between diastolic BPV and ascending aorta diameter.…”

Section: Discussionsupporting

confidence: 50%

“…16 Moreover, nighttime BPV was found to be related to adverse cardiovascular events. 17 However, Tatasciore et al reported that nighttime systolic BPV was not correlated with target-organ damage in patients with untreated and recently diagnosed hypertension. 18 Similarly, in our study, nighttime BPV was not correlated with aortic size index, but 24-hour and daytime systolic BPV were found to be positively correlated with aortic size index in recently diagnosed hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Short‐term Blood Pressure Variability in Patients With Ascending Aortic Dilatation

Karataş

İpek

Çanga

et al. 2015

Clinical Cardiology

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Background: Blood pressure variability (BPV) is a novel parameter related to adverse cardiovascular findings and events, especially in hypertensive patients. The aim of the present study was to investigate the relationship between short-term BPV and ascending aortic dilatation (AAD). Hypothesis: Hypertensive patients with AAD may exhibit higher short-term BPV compared to hypertensive patients with normal diameter ascending aorta and BPV may be correlated with aortic sizes. Methods: Seventy-six hypertensive patients with AAD and 181 hypertensive patients with a normal-diameter ascending aorta were retrospectively enrolled in the study. Clinical data, echocardiographic characteristics, and 24-hour ambulatory blood pressure monitoring characteristics were compared between the 2 groups. Standard deviation (SD) and of BP were used as parameters of BPV. Results: Although 24-hour mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similar between the 2 groups, the SD of SBP and SD of DBP values were significantly higher in AAD patients (17.2 ± 6.8 vs 13.8 ± 3.5, P < 0.01; and 12.1 ± 5.1 vs 10.7 ± 3.1, P = 0.02, respectively). Daytime SD of SBP values were higher in AAD patients, whereas nighttime SD of SBP values did not differ between groups. In multivariate linear regression analysis, 24-hour SD of SBP, 24-hour SBP, daytime SD of SBP, daytime SBP, and left ventricular mass index were independently correlated with aortic size index. Conclusions: Our study revealed higher levels of short-term BPV in hypertensive patients with AAD. This conclusion warrants further study.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Assessment of Short‐term Blood Pressure Variability in Patients With Ascending Aortic Dilatation

Karataş

İpek

Çanga

et al. 2015

Clinical Cardiology

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“…Можливим Дані щодо зв'язку варіабельності АТ із рестено-зами після перкутанних коронарних втручань [11] та з ризиком коронарного ураження при цукровому діабеті [37] свідчать, що, можливо, саме підвищена варіабельність АТ є одним із патогенетичних чин-ників виникнення (або прогресування) ІХС. Окрім того, варіабельність може асоціюватися також із частотою виникнення інсульту та інфаркту міокар-да [12,42].…”

Section: клінічні дослідження / Clinicial Researchesunclassified

Порівняння Впливу Фіксованої Комбінації Периндоприл/Амлодипін На Ураження Органів-Мішеней У Пацієнтів З Артеріальною Гіпертензією З ішемічною Хворобою Серця Та Без Неї (Результати Дослідження EPHES)

Radchenko

Mushtenko

Torbas

et al. 2022

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“…Considering this association, the authors stress out that the assessment of shortterm BPV could potentially add to the early detection of normotensive Africans at increased risk for the development of cardiovascular complications [35]. Data from Ozawa et al also suggest that increased shortterm BPV estimated by ABPM represents a coronary risk factor in diabetic hypertensive patients [36]. By comparing hemodynamics of patients with or without coronary artery disease, the authors found greater nighttime systolic BPV in the absence of significant differences in mean BP values in diabetic patients with coronary artery disease with regard to subjects without coronary artery disease [36].…”

Section: Clinical Impact Of Short-term Bpv On Target Organ Damage Andmentioning

confidence: 99%

Blood Pressure Variability: Prognostic Value and Therapeutic Implications

Höcht

2013

ISRN Hypertension

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Blood pressure variability (BPV) is considered nowadays a novel risk factor for cardiovascular disease. Early findings in sinoaortic denervated rats have clearly shown that enhanced fluctuation of blood pressure induced left ventricular hypertrophy, vascular stiffness, and renal lesion. A large number of clinical trials confirm that short-term and long-term blood pressure variability independently contributes to target organ damage, cardiovascular events, and mortality not only in hypertensive patients but also in subjects with diabetes mellitus and chronic kidney disease. Therefore, amelioration of BPV has been suggested as an additional target of the treatment of cardiovascular diseases. Preliminary evidence obtained from meta-analysis and controlled clinical trials has shown that antihypertensive classes differ in their ability to control excessive BP fluctuations with an impact in the prevention of cardiovascular events. Calcium channel blockers seem to be more effective than other blood pressure lowering drugs for the reduction of short-term and long-term BPV. In order to increase actual knowledge regarding the prognostic value and therapeutic significance of BPV in cardiovascular disease, there is a need for additional clinical studies specifically designed for the study of the relevance of short-term and long-term BPV control by antihypertensive drugs.

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Identification of an Increased Short-Term Blood Pressure Variability on Ambulatory Blood Pressure Monitoring as a Coronary Risk Factor in Diabetic Hypertensives

Cited by 33 publications

References 34 publications

Assessment of Short‐term Blood Pressure Variability in Patients With Ascending Aortic Dilatation

Assessment of Short‐term Blood Pressure Variability in Patients With Ascending Aortic Dilatation

Blood Pressure Variability: Prognostic Value and Therapeutic Implications

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