Identification of an enolase gene and its physiological role in Spirometra mansoni

Liang, Pei; Cui, Xing; Fu, Ruonong; Peng, Liang; Lü, Gang; Wang, Dayong

doi:10.1007/s00436-021-07175-y

Cited by 3 publications

(1 citation statement)

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“…To successfully complete their life cycle, Spirometra tapeworms must navigate the challenges of environmental shifts between hosts and excel in intricate processes involving host invasion and immune evasion. These processes entail the intricate expression, recognition, and interaction of numerous biological molecules [18,19]. To fully understand how parasites and hosts interact and to nd pivotal factors in immune regulation and evasion, it is important to analyze the protein pro les of Spirometra tapeworms at different stages of development stages [20].…”

Section: Introductionmentioning

confidence: 99%

Comparative proteomics analysis of the egg, sparganum, and adult stages of Spirometra mansoni

Liu,

Gong,

et al. 2024

Preprint

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Background The plerocercoid larvae of Spirometra mansoni (S. mansoni) can invade the human body, causing a severe parasitic zoonotic disease known as sparganosis. Methods To gain insights into the developmental process of S. mansoni, it is crucial to comprehend the specific gene and protein expressions that allow the parasite to adapt to environmental changes between intermediate and definitive hosts. In this study, we employed tandem mass tag (TMT) analysis to compare proteomic changes among three developmental stages of S. mansoni: the egg, sparganum, and adult stages. Results We identified significant differential expression in a total of 1730 proteins in the sparganum compared to the egg groups and 1308 proteins in the adult compared to the sparganum groups. The functional annotation of these differentially expressed proteins (DEPs) unveiled pronounced metabolic disparities among these developmental stages. The sparganum stage exhibited overexpression of proteins primarily linked to migration and immune evasion, which underpins its potent immune escape mechanism and robust invasion capabilities. In contrast, the adult stage displayed an upregulation of proteins associated with functions related to protein biosynthesis, including translation, peptide biosynthetic processes, amide biosynthetic processes, and peptide metabolic processes. Conclusions These findings highlight new insights into the proteomic changes across S. mansoni developmental stages, potentially offering valuable targets for diagnosis and therapy.

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Section: Introductionmentioning

confidence: 99%