Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice

Phellinus linteus grown on germinated brown rice Suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-κB and Wnt/β-catenin Signaling Pathways

“…reports, we observed that PBR EtOAc extract decreased phosphorylation of Akt, p38 and ERK. Previously we reported several compounds were isolated from PBR, which were not observed in regular P. linteus (Jeon et al, 2013;. In vivo efficacy studies of these compounds should be done in the future.…”

“…Gelatinase activities were measured using zymography analysis as described previously (Jeon et al, 2013). Briefly, culture media were collected and centrifuged at 5635 g for 1 h to remove cell debris.…”

“…In a previous study, we reported that P. linteus grown on germinated brown rice (PBR) had anti-tumor activities, which inhibited tumor metastasis in mice and induced apoptosis associated with cell cycle arrest at the G0/G1 phase in human colon cancer cells (Park, Choi, Hong, Hwang, & Park, 2010). In a second study, we isolated atractylenolide I from PBR which exerted anticancer effect against colon cancer cells (Jeon, Jung, Cho, Park, & Moon, 2013). In a third study, the PBR extract was found to have anti-inflammatory activity in LPS-stimulated RAW264.7 cells by virtue of its ability to suppress the production of inflammatory cytokines and chemokines via inhibition of mitogen-activated protein kinase (MAPK) activation and upregulation of antioxidant activities (Park, Han, Park, Lee, & Lee, 2010).…”

Kinetic models for the effect of temperature on flavonoid production in liquid submerged fermentation by Phellinus baumii

“…It has been used as dietary supplement for health improvement in China for thousands of years. However, little is known that flavonoids are the important active components of P. baumii , and flavonoids isolated from P. baumii have been demonstrated to have various bioactivities, such as antiviral, anti‐inflammatory, antitumor, and antioxidation . Also, flavonoids were widely used in health foods, drugs, and cosmetics .…”

Exploring growth-inhibitory and immuno-stimulatory activity in British Columbia wild mushrooms and lichens

“…Crude extracts can elicit immunomodulatory, as well as direct antitumor activity through apoptosis 58 . Phellinus linteus shows promise in the treatment of lung cancer 59 , invasive breast cancer 60 , benign prostatic hyperplasia 61 , and colon adenocarcinoma 62 ; it is also able to inhibit tumor growth in mice inoculated with sarcoma-180 tumor cells 63 . Interestingly, a primarily polysaccharide extract of P. linteus has been seen to have a synergistic effect when used in conjunction with doxorubicin (a chemotherapeutic), sensitizing prostate cancer cells to the cytotoxic effects of this drug, activating caspase cascade leading to apoptosis 64 .…”