Identification of an anti-bacterial agent in toothpaste via liquid chromatography-Fourier transform infrared spectrometry mobile phase elimination

Jordan, Sheri L.; Taylor, Larry T.; McPherson, Bruce P.; Rasmussen, Henrik T.

doi:10.1016/s0021-9673(96)00624-3

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…High initial concentration of the aqueous available TCN will enhance its delivery to the various sites of action (substantivity). Regulatory requirements dictate the assay of TCN to be made for every production batch and determination of its contamination in rivers and lakes [5][6][7]. The analysis is beset with problems due to poor analyte 0022-0728/$ -see front matter Ó 2005 Elsevier B.V. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

“…The analysis is beset with problems due to poor analyte 0022-0728/$ -see front matter Ó 2005 Elsevier B.V. All rights reserved. doi:10.1016/j.jelechem.2005.08.003 peak shapes, matrix interference and even column degradation in chromatographic [5][6][7][8] techniques, which require time-consuming pre-treatment steps. Recently, Pemberton and Hart [9] have successfully exploited the electroactive nature of TCN to demonstrate its voltammetric determination in oral care products (PVM/ MA copolymers in the formulations do not seem to ''deactivate'' as seen in our studies and as observed by Prencipe et al [10]).…”

Section: Introductionmentioning

confidence: 99%

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Hydrotrope-driven disruption of micellar encapsulants for voltammetric detection of triclosan

Raghupathy

Mathiyarasu

Joseph

et al. 2005

Journal of Electroanalytical Chemistry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrotrope-driven disruption of micellar encapsulants for voltammetric detection of triclosan

Raghupathy

Mathiyarasu

Joseph

et al. 2005

Journal of Electroanalytical Chemistry

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Liquid Chromatography/Infrared Spectroscopy

Visser

2000

Encyclopedia of Analytical Chemistry

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Analytical techniques that combine liquid chromatography (LC) and infrared (IR) spectroscopy have been developed primarily to permit specific detection and/or identification of sample constituents. LC is an important and extensively used method for the separation of mixtures into their individual components. IR spectroscopy is very useful for the characterization of functional groups and has strong compound‐identification capabilities which are especially suited for the differentiation of structural isomers. Over the past years the coupling of LC and IR spectroscopy (LC/IR) has been accomplished by two different approaches. The first and simplest approach is to use a flow cell through which the effluent from the LC column is passed while the IR spectra are continuously measured. The merits of flow‐cell IR detection include ease of operation, real‐time detection and low maintenance, but its main disadvantage lies in the significant IR‐absorption of the solvents commonly used in LC. These absorptions seriously limit both the detection sensitivity and the obtainable spectral information. The second approach involves elimination of the LC solvent prior to IR detection. In this approach an interface is used to evaporate the eluent and deposit the separated compounds onto a substrate suitable for IR detection. The primary advantages of solvent‐elimination LC/IR are the possibility to obtain full spectra of the analytes and the considerably enhanced sensitivity when compared to flow‐cell detection. Unfortunately, common LC solvents, and particularly aqueous eluents, are not easily removed and therefore the evaporation interfaces are often rather complex. This article reviews the developments, practical aspects, applications and current status of LC/IR, covering both coupling approaches. It follows that despite the unfavorable detection limits, flow‐cell LC/IR can be useful for the specific and quantitative detection of major components of mixtures. However, solvent‐elimination‐based IR‐detection should be used when small amounts of sample constituents have to be characterized with a high level of confidence. In general, the practical use of IR detection in LC is still limited, but the advent of various (commercial) flow‐cell and interface designs shows that LC/IR is more and more being recognized as a feasible and rewarding technique.

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Assessment of dentifrice adulteration with diethylene glycol by means of ATR-FTIR spectroscopy and chemometrics

López-Sánchez

Domínguez‐Vidal

Ayora‐Cañada

et al. 2008

Analytica Chimica Acta

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Identification of an anti-bacterial agent in toothpaste via liquid chromatography-Fourier transform infrared spectrometry mobile phase elimination

Cited by 7 publications

References 6 publications

Hydrotrope-driven disruption of micellar encapsulants for voltammetric detection of triclosan

Hydrotrope-driven disruption of micellar encapsulants for voltammetric detection of triclosan

Liquid Chromatography/Infrared Spectroscopy

Assessment of dentifrice adulteration with diethylene glycol by means of ATR-FTIR spectroscopy and chemometrics

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