Identification of an Alepterolic Acid Derivative as a Potent Anti‐Breast‐Cancer Agent via Inhibition of the Akt/p70S6K Signaling Pathway
Nina Wang,
Lei Zhang,
Junjie Yu
et al.
Abstract:Alepterolic acid is a diterpene occurring in the fern Aleuritopteris argentea with potentially biological activity warrant further structural modification. In the present work, sixteen alepterolic acid derivatives were synthesized and evaluated for their anti‐cancer activities. Among them, N‐[m‐(trifluoromethoxy)phenyl] alepterolamide displayed comparable activity (IC50=4.20±0.21 μM) in MCF‐7 cells. Moreover, mechanistic investigations indicated this compound was significantly capable of diminishing cell prol… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.