Identification of adenoid biofilms in chronic rhinosinusitis

Zuliani, Giancarlo; Carron, Michael A.; Gurrola, José; Coleman, C.N.; Haupert, Michael; Berk, Richard S.; Coticchia, James M.

doi:10.1016/j.ijporl.2006.05.002

Cited by 123 publications

(104 citation statements)

References 23 publications

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“…Similarly, in a group of pediatric patients with CRS, adenoidectomy specimens revealed that nearly 95% of their surface was covered by mature bacterial biofilms. At the same time, specimens from control patients revealed very little coverage (< 2%) [30]. Finding these bacterial biofilms in patients with chronic adenotonsillar disease supports the notion that these chronic illnesses may be secondary to bacterial infection in a nonplanktonic form, which has been shown to be difficult to eradicate with current antimicrobial therapies.…”

Section: Adenotonsillar Diseasementioning

confidence: 66%

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

Kilty¹,

Desrosiers

2008

Curr Allergy Asthma Rep

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The earliest description of a bacterial biofilm is likely centuries old. However, only in the past few decades has a wealth of knowledge developed pertaining to this bacterial form of existence. Biofilms have been implicated mainly in chronic disease states, and the current available treatment modalities for infection have demonstrated limited efficacy against bacteria in this form. There is evidence associating bacterial biofilm formation in chronic infections of the upper airway, and therefore we examine the possible role of a bacterial biofilm in chronic rhinosinusitis while drawing parallels with recent data from other bodily regions. Lastly, directions for contemporary biofilm research are reviewed and highlighted in terms of their application to chronic rhinosinusitis.

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Section: Adenotonsillar Diseasementioning

confidence: 66%

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

Kilty¹,

Desrosiers

2008

Curr Allergy Asthma Rep

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“…Table 2 also presents the hazard ratio (HR) for developing OAG over the 5-year follow-up period between the study cohort and the comparison cohort. A cox proportional hazards regression stratified by sex, age group, urbanization level, and index year, suggested that the HR for developing OAG over the 5-year follow-up period for the study cohort was 1 Figure 1 Procedures of the cases selection. (95% CI: 1.53-1.96) when compared with the comparison cohort after adjusting for monthly income, geographic region, hypertension, diabetes, CHD, hyperlipidemia, and hypothyroidism and censoring the cases who died over the 5-year follow-up period.…”

Section: Resultsmentioning

confidence: 99%

“…1,2 CRS is one of the most common diseases in the otolaryngologic field, affecting between 18 and 22 million adults in the United States each year. 3 In Europe, CRS also affects over 10% of the population.…”

Section: Introductionmentioning

confidence: 99%

Increased risk of open-angle glaucoma following chronic rhinosinusitis: a population-based matched-cohort study

Chung

Lin

et al. 2013

Eye

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Purpose Anatomically, the eyes and paranasal sinuses are neighboring structures and some studies have mentioned eye disease in conjunction with chronic rhinosinusitis (CRS). However, to the best of our knowledge, no prior research has investigated the risk of developing openangle glaucoma (OAG) among CRS patients. This study aims to provide an estimated risk of developing OAG among patients with CRS by using a population-based data set in Taiwan. Methods This retrospective cohort study used data sourced from the 'Longitudinal Health Insurance Database 2000'. A total of 15 642 CRS patients were included in the study cohort and 46 926 subjects were randomly extracted as a comparison cohort. A cox proportional-hazards regression analysis was performed to calculate the 5-year risk of subsequently developing OAG following a diagnosis of CRS between the study cohort and the comparison cohort. Results The incidence rate of developing OAG over the 5-year follow-up period was 5.45 (95% CI: 4.95-5.98) per 1000 person-years for the study cohort and 2.80 (95% CI: 2.60-3.03) per 1000 person-years for the comparison cohort. After censoring the cases that died over the 5-year period and adjusting for the factors of monthly income, geographic region, hypertension, diabetes, coronary heart disease, hyperlipidemia, and hypothyroidism the hazard ratio for developing OAG over the 5-year period for subjects with CRS to subjects without CRS was 1.73 (95% CI: 1.53-1.96). Conclusion We found that those subjects with CRS had a significantly higher risk of developing OAG over the 5-year follow-up period as compared with subjects without CRS.

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“…These infections are more difficult to treat because of the highly resistant nature of the bacterial biofilms against antibiotics and host response (21). In the field of otolaryngology, biofilms have been reported in otitis media with effusion, cholesteatoma and tonsillitis, rhinosinusitis and adenoids removed from children with chronic rhinosinusitis (CRS), and they have also been isolated on some prosthetic devices, such as tracheotomy and tympanostomy tubes and cochlear implants (8,(22)(23)(24)(25).…”

Section: Biofilms In Otolaryngologic Disease Statesmentioning

confidence: 99%

Biofilms in Otolaryngology

Develioğlu¹,

Külekçi²

2013

JAREM

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Biofilms have been shown to play an important role in otolaryngologic disorders. Recent advances have demonstrated that there are different bacterial species within the biofilms in different disease states. Since the recognition that chronic otolaryngologic infections are associated with biofilms, new treatment strategies with new agents have been trying to be developed for antibiotic-resistant bacterial biofilms. It has been well known that inadequate doses of antibiotic treatment can trigger biofilm formation and can lead to chronic infections. In fact, to diagnose, treat and prevent biofilm-related illnesses, different strategies are required. Determining the bacterial genetics of biofilm formation and the interaction between host and bacteria will provide substantial targets for biofilm drug therapies. The main goal of this review is to evaluate and discuss in detail some of the recent findings in biofilms-related otolaryngologic states. (JAREM 2013; 3: 1-4) Key Words: Biofilm, otolaryngology ÖZETBiofilmlerin otolarengolojik hastalıklarda önemli bir rolü olduğu gösterilmiştir. Yakın zamanda yapılan çalışmalarda farklı hastalık durumlarında biofilmlerin içinde farklı mikroorganizma türlerinin bulunduğu saptanmıştır. Kronik otolarengolojik infeksiyonların biofilmler ile ilişkili olduğu anlaşıldıktan sonra, özellikle antibiyotiklere dirençli olduğu bilinen bakteriyel biofilmler için yeni ajanları içeren tedavi stratejilerinin geliştirilmesine çalışılmaktadır. Uygun olmayan dozlarda antibiyotik tedavisi biofilm oluşumunu ve kronik enfeksiyonların gelişimini tetikleyebilir. Biofilmler ile ilişkili hastalıkların tanısı, tedavisi ve önlenmesi için farklı stratejilere gereksinim vardır. Biofilm oluşumunun bakteriyel genetik alt yapısının saptanması ve konak ile bakteri arasındaki etkileşimin anlaşılması, biofilme bağlı enfeksiyonların tedavisi için doğru hedeflerin belirlenmesini sağlayacaktır. Bu derlemenin esas amacı biofilm ile ilişkili otolarengolojik hastalıklardaki yeni gelişmelerin detaylı bir şekilde tartışılarak değerlendirilmesidir. (JAREM 2013; 3: 1-4) Anahtar Sözcükler: Biofilm, otolarengoloji

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Identification of adenoid biofilms in chronic rhinosinusitis

Cited by 123 publications

References 23 publications

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

Increased risk of open-angle glaucoma following chronic rhinosinusitis: a population-based matched-cohort study

Biofilms in Otolaryngology

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