Identification of additives in polymers from single-use bioprocessing bags by accelerated solvent extraction and ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry

Dorival-García, Noemí; Galbiati, Fabrizio; Kruell, Ralf; Kovàsy, Roman; Dunne, Simon O; D’Silva, Kyle; Bones, Jonathan

doi:10.1016/j.talanta.2020.121198

Cited by 15 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accelerated solvent extraction with gas chromatography mass spectrometry (ASE GC-MS) An organic additive screen was conducted on all substrates using previously established methods utilizing GC-MS with minor adjustments. 37,125 For GC-MS analysis, accelerated solvent extraction (ASE) was conducted using a Model ASE 200 (Dionex, Germany). 500 mg to 1 g of cryomilled sample was mixed with diatomite to fill an ASE extraction cell.…”

Section: Fluorine Analysismentioning

confidence: 99%

Characterization of polymer properties and identification of additives in commercially available research plastics

Cuthbertson,

Lincoln,

Miscall

et al. 2024

Green Chem.

View full text Add to dashboard Cite

show abstract

Section: Fluorine Analysismentioning

confidence: 99%

Characterization of polymer properties and identification of additives in commercially available research plastics

Cuthbertson,

Lincoln,

Miscall

et al. 2024

Green Chem.

View full text Add to dashboard Cite

show abstract

“…To determine whether OPEs were exhaustively extracted from the SHLB packaging material, ASE was further employed for comparison with water and hexane extractions. 30 Hexane and dichloromethane (1:1, v/v) were used for the extraction of packaging materials (n = 3) at a temperature of 120 °C and a pressure of 10.3 MPa, with two static cycles and a purge time of 120 s. The following procedures were identical to those performed for hexane extraction.…”

Section: Migration and Extractionmentioning

confidence: 99%

Convenient Self-Heating Instant Food Causes Significant Increasing Human Exposure to Organophosphate Esters

Li,

Yin,

Zhou

et al. 2023

Environ. Health

View full text Add to dashboard Cite

The self-heating lunch box (SHLB) is a kind of popular instant food in China, yet little is known about the associated chemical release risk during its heating process. In this study, we investigated organophosphate esters (OPEs) in original unheated food (UF), SHLB-heated processed food (HF) and potential OPE release from SHLB packaging materials. Significantly higher concentrations of OPEs were observed in HF (267 ± 246 ng/g dry weight (dw)) than in UF (163 ± 211 ng/g dw) (p < 0.001), suggesting an introduction of additional OPEs during heating processes. Tris(2-chloroethyl) phosphate, triethyl phosphate, and tris(2-chloroisopropyl) phosphate exhibited the highest absolute increased amounts, with 137, 48.8, and 149% growth in HF than in UF, respectively. Migration testing revealed that packaging materials were rich in OPEs and can release considerable OPEs into food simulates (range, 14.7−90.8 ng/g; mean, 47.9 ± 21.8). Influencing factors (temperature, contact time, oily food) on OPE migration from packaging materials to food were assessed. Higher temperature and longer contact time increased OPE contents in food simulates. Moreover, the presence of abundant OPEs in UF and significant correlations among different OPEs (p < 0.05) suggested contamination happened during food processing and storage. With one SHLB meal a day, a 12-fold increase of OPE intake was observed for humans compared to those following a traditional dietary habit. In the high-exposure (95th percentile) scenario, hazard quotients of nine OPEs ranged from 0.00005 to 0.05. Our results suggested that the SHLB exposure pathway of OPEs should be particularly paid attention to in specific subpopulations that prefer this dietary habit.

show abstract

“…214 Various scoring algorithms are available, and their selection and implementation are known to affect predictivity, 215 though specific algorithms and settings are often unreported. Dot-product-based scoring methods (e.g., as in the NIST 1A GC/MS library 83,97,216 ) that are based on the number of matching fragment ions and the sum of intensity differences can be used to calculate the match score. 217 For LC/MS, the use of public databases such as MassBank and mzCloud 83 have been reported.…”

Section: ■ Extractionmentioning

confidence: 99%

Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

Sussman

Öktem

Isayeva

et al. 2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

The developers of medical devices evaluate the biocompatibility of their device prior to FDA’s review and subsequent introduction to the market. Chemical characterization, described in ISO 10993-18:2020, can generate information for toxicological risk assessment and is an alternative approach for addressing some biocompatibility end points (e.g., systemic toxicity, genotoxicity, carcinogenicity, reproductive/developmental toxicity) that can reduce the time and cost of testing and the need for animal testing. Additionally, chemical characterization can be used to determine whether modifications to the materials and manufacturing processes alter the chemistry of a patient-contacting device to an extent that could impact device safety. Extractables testing is one approach to chemical characterization that employs combinations of non-targeted analysis, non-targeted screening, and/or targeted analysis to establish the identities and quantities of the various chemical constituents that can be released from a device. Due to the difficulty in obtaining a priori information on all the constituents in finished devices, information generation strategies in the form of analytical chemistry testing are often used. Identified and quantified extractables are then assessed using toxicological risk assessment approaches to determine if reported quantities are sufficiently low to overcome the need for further chemical analysis, biological evaluation of select end points, or risk control. For extractables studies to be useful as a screening tool, comprehensive and reliable non-targeted methods are needed. Although non-targeted methods have been adopted by many laboratories, they are laboratory-specific and require expensive analytical instruments and advanced technical expertise to perform. In this Perspective, we describe the elements of extractables studies and provide an overview of the current practices, identified gaps, and emerging practices that may be adopted on a wider scale in the future. This Perspective is outlined according to the steps of an extractables study: information gathering, extraction, extract sample processing, system selection, qualification, quantification, and identification.

show abstract

Identification of additives in polymers from single-use bioprocessing bags by accelerated solvent extraction and ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry

Cited by 15 publications

References 31 publications

Characterization of polymer properties and identification of additives in commercially available research plastics

Characterization of polymer properties and identification of additives in commercially available research plastics

Convenient Self-Heating Instant Food Causes Significant Increasing Human Exposure to Organophosphate Esters

Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

Contact Info

Product

Resources

About