Identification of Abnormal Neuromagnetic Signatures in the Motor Cortex of Adolescent Migraine

Wang, Xiaoshan; Xiang, Jing; Wang, Yingying; Pardos, Maria; Liu, Meng; Huo, Xing; Korostenskaja, Milena; Powers, Scott W.; Kabbouche, Marielle A.; Hershey, Andrew D.

doi:10.1111/j.1526-4610.2010.01674.x

Cited by 19 publications

(49 citation statements)

References 51 publications

(170 reference statements)

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“…Patients with migraine also frequently have cog-nitive changes during an acute attack including difficulty concentrating, thinking, feeling disoriented, or performing slowly on complex mental tasks (Pietrini et al, 1987). These observations support the conclusion that migraine is a neurological disease with disturbance in cerebral function and were further assessed with neuropsychological studies (Wang et al, 2010).…”

Section: Introductionmentioning

confidence: 93%

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Impaired Auditory Information Processing During Acute Migraine: A Magnetoencephalography Study

Korostenskaja

Pardos

Kujala

et al. 2011

International Journal of Neuroscience

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Acute migraine could be associated with neurophysiological and cognitive changes. This study evaluates the neurophysiological changes in auditory information processing in adolescents with acute migraine by means of magnetoencephalography. The multifeature sound mismatch negativity (MMN) paradigm was used to study nine adolescents with an acute migraine and nine age- and gender-matched healthy controls. Latencies and amplitudes of M100, M150, M200, and MMNm responses were evaluated. Migraine subjects had smaller M150 amplitudes than healthy subjects. The latencies of MMNm response for the frequency change were delayed in both hemispheres in migraine subjects, as compared with healthy controls. Our results indicate that the function of neural substrates, responsible for different stages of auditory information processing, is impaired during the acute migraine. The identification of underlying cortical dysfunction during an acute migraine can lead to future identification of neurophysiological biomarkers for studying acute migraine and response to treatment.

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Section: Introductionmentioning

confidence: 93%

“…We used standard MEG recording procedure previously described in publications by our group (Wang et al, 2010). During the MEG recordings, each subject reclined comfortably in the supine position in an electromagnetically shielded room (VACUUMSCHMELZE GmbH&Co., Hanau, Germany (Fuchs, Kastner, Wagner, Hawes, & Ebersole, 2002).…”

Section: Data Acquisitionmentioning

confidence: 99%

Impaired Auditory Information Processing During Acute Migraine: A Magnetoencephalography Study

Korostenskaja

Pardos

Kujala

et al. 2011

International Journal of Neuroscience

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“…Similarly to previous reports 22, 35 , subjects were instructed to press a response button immediately after the presentation of a 500 Hz square wave tone. Subjects were instructed to use the index finger that was ipsilateral to the ear that the tone was played in, while keeping other body parts still with eyes open and fixed to a target on the screen in front of them during the tests (see Fig.…”

Section: Methodsmentioning

confidence: 99%

“…The stimuli consisted of 200 trials of tones, 100 trials per ear, which were presented randomly through plastic tubes and earphones. Stimulus presentation and response recording were accomplished with BrainX software, which was based on DirectX (Microsoft Corporation, Redmond, WA, USA) 22, 35 .…”

Section: Methodsmentioning

confidence: 99%

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Spatial Heterogeneity of Cortical Excitability in Migraine Revealed by Multifrequency Neuromagnetic Signals

Xiang

Leiken

deGrauw

et al. 2016

The Journal of Pain

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To investigate the spatial heterogeneity of cortical excitability in adolescents with migraine, magnetoencephalography (MEG) recordings at a sampling rate of 6000 Hz were obtained from 35 adolescents with an acute migraine and 35 age- and gender-matched healthy controls during an auditory-motor task. Neuromagnetic activation from low- to high-frequency ranges (5–1,000 Hz) was measured at both sensor and source levels. The heterogeneity of cortical excitability was quantified within each functional modality (auditory vs. motor) and hemispherical lateralization. MEG data showed that high-frequency, not low-frequency neuromagnetic signals, revealed heterogeneous cortical activation in migraine subjects as compared with controls (p < 0.001). The alteration of the heterogeneity of cortical excitability in migraine was independent of age and gender. The degree of the neuromagnetic heterogeneity of cortical activation was significantly correlated with headache frequency (r=0.71, p < 0.005). The alteration of cortical excitability in migraine is spatially heterogeneous and frequency dependent, which has not previously been reported. The finding may be critical for developing spatially targeted therapeutic strategies for normalizing cortical excitability with the purpose of reducing headache attacks. Perspective This article presents a new approach to quantitatively measuring the spatial heterogeneity of cortical excitability in adolescents with migraine using MEG signals in a frequency range of 5–1000 Hz. The characteristics of the location and degree of cortical excitability may be critical for spatially targeted treatment for migraine.

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Altered functional magnetic resonance imaging resting‐state connectivity in periaqueductal gray networks in migraine

Mainero

Boshyan

Hadjikhani

2011

Annals of Neurology

329

290

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Summary Objective The periaqueductal gray matter (PAG), a known modulator of somatic pain transmission, shows evidence of interictal functional and structural abnormalities in migraineurs, which may contribute to hyperexcitability along spinal and trigeminal nociceptive pathways, and lead to the migraine attack. The aim of this study was to examine functional connectivity of the PAG in migraine. Methods Using resting-state functional MRI, we compared functional connectivity between PAG and a subset of brain areas involved in nociceptive/somatosensory processing and pain modulation in 17 subjects with migraine, during a pain free state, versus 17 gender- and age-matched controls. We also assessed the relation between intrinsic resting-state correlations within PAG networks and the average monthly frequency of migraine attacks, as well as allodynia. Results Our findings show stronger connectivity between the PAG and several brain areas within nociceptive and somatosensory processing pathways in migraineurs versus controls. In addition, as the monthly frequency of migraine attacks worsens, the strength of the connectivity in some areas within these pathways increases while a significant decrease in functional resting-state connectivity between the PAG and brain regions with a predominant role in pain modulation (prefrontal cortex, anterior cingulate, amygdala) can be evidenced. Finally, migraineurs with a history of allodynia exhibit significantly reduced connectivity between PAG, prefrontal regions and anterior cingulate compared to migraineurs without allodynia. Conclusions These data reveal interictal dysfunctional dynamics within pain pathways in migraine manifested as an impairment of the descending pain modulatory, likely leading to loss of pain inhibition, and hyperexcitability primarily in nociceptive areas.

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Identification of Abnormal Neuromagnetic Signatures in the Motor Cortex of Adolescent Migraine

Cited by 19 publications

References 51 publications

Impaired Auditory Information Processing During Acute Migraine: A Magnetoencephalography Study

Impaired Auditory Information Processing During Acute Migraine: A Magnetoencephalography Study

Spatial Heterogeneity of Cortical Excitability in Migraine Revealed by Multifrequency Neuromagnetic Signals

Altered functional magnetic resonance imaging resting‐state connectivity in periaqueductal gray networks in migraine

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