Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma

Wang, Kai; Qu, Xiao; Liu, Shaorui; Yang, Xudong; Bie, Fenglong; Wang, Yu; Huang, Can; Du, Jiajun

doi:10.1007/s00432-018-2653-1

Cited by 28 publications

(26 citation statements)

References 46 publications

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“…A recent study based on data collected from the TCGA and Gene Expression Omnibus (GEO) databases showed that the expression of FBXO45 and FBXO5 was apparently increased in squamous cell lung cancer (SqCLC) compared with normal lung tissues [122]. Similarly, a prognostic analysis conducted by the K-M plotter database also revealed that overexpression of FBXO45 and FBXO5 contributed to shorter overall survival in patients with SqCLC [122]. Further molecular experiments showed that knockdown of FBXO5 increased cell apoptosis but that knockdown of FBXO45 promoted EMT in SqCLC cells [122].…”

Section: Regulation Of Emt By F-box Proteinsmentioning

confidence: 99%

Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers

et al. 2019

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Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box proteins are critically involved in the regulation of the EMT process and stem cell differentiation in human cancers. In this review, we will briefly describe the role of EMT and stem cells in cell metastasis and drug resistance. We will also highlight how numerous F-box proteins govern the EMT process and stem cell survival by controlling their downstream targets. Additionally, we will discuss whether F-box proteins involved in drug resistance are associated with EMT and cancer stem cells. Targeting these F-box proteins might be a potential therapeutic strategy to reverse EMT and inhibit cancer stem cells and thus overcome drug resistance in human cancers.

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Section: Regulation Of Emt By F-box Proteinsmentioning

confidence: 99%

Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers

et al. 2019

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“…1). Compared with that in normal lung tissue, FBXO45 is highly expressed in squamous-cell lung carcinoma (SCLC) tissues according to TCGA and Gene Expression Omnibus data 21 . Compared with that in adjacent tissues, an increased level of FBXO45 was confirmed in SCLC tissues by reverse transcription polymerase chain reaction analysis.…”

Section: Fbxo45 Is Highly Overexpressed In Human Cancer Tissuesmentioning

confidence: 99%

“…Compared with that in adjacent tissues, an increased level of FBXO45 was confirmed in SCLC tissues by reverse transcription polymerase chain reaction analysis. Furthermore, it was also illustrated that high expression of FBXO45 was correlated with poor survival in patients with SCLC by obtaining data from the Kaplan-Meier plotter website and the TCGA database 21 . Consistent with the results in SCLC, FBXO45 expression was higher in gastric cancer tissues than in normal gastric tissues 22 .…”

Section: Fbxo45 Is Highly Overexpressed In Human Cancer Tissuesmentioning

confidence: 99%

“…Likewise, FBXO45 inhibited EMT by targeting EMT-inducing transcription factors, including Zeb1/2, Snai1/2 and Twist1, for ubiquitination and degradation in cancer cells 30 . FBXO45 was related to several biological processes, including cell adhesion, immune response, cell signal transduction and angiogenesis, in GO and KEGG pathways analyses 21 . Interestingly, a study in SCLC further revealed that diminished expression of FBXO45 blocked the colony forming ability of H520 cells, but markedly augmented migration and prompted EMT 21 .…”

Section: Identified Substrates and Functions Of Fbxo45mentioning

confidence: 99%

“…FBXO45 was related to several biological processes, including cell adhesion, immune response, cell signal transduction and angiogenesis, in GO and KEGG pathways analyses 21 . Interestingly, a study in SCLC further revealed that diminished expression of FBXO45 blocked the colony forming ability of H520 cells, but markedly augmented migration and prompted EMT 21 . Although these studies explored the molecular mechanisms of FBXO45-related tumorigenesis and progression (Fig.…”

Section: Identified Substrates and Functions Of Fbxo45mentioning

confidence: 99%

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FBXO45 is a potential therapeutic target for cancer therapy

2020

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FBXO protein 45 (FBXO45), a substrate-recognition subunit of E3 ligases, has been characterised to have pivotal roles in many human diseases, including nervous system diseases, inflammatory diseases and human malignancies. In this article, we describe the expression of FBXO45 in several types of human tumour specimens and highlight the downstream substrates of FBXO45. Moreover, the biological functions of FBXO45 in the regulation of proliferation, apoptosis, the cell cycle and metastasis are mentioned. Furthermore, we describe that the expression level of FBXO45 is regulated by several upstream factors such as miR-27a, Hey1, m 6 A and the lncRNA RP11. As FBXO45 has a critical role in tumorigenesis and progression, FBXO45 might be a novel therapeutic target for cancer treatment. Facts • FBXO45 exerts its functions by targeting substrates for ubiquitination and degradation. • FBXO45 has a pivotal role in carcinogenesis and progression. • Targeting FBXO45 might be a novel strategy for cancer therapy.

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Skp2 in the ubiquitin‐proteasome system: A comprehensive review

Asmamaw

Liu

Zheng

et al. 2020

Medicinal Research Reviews

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The ubiquitin‐proteasome system (UPS) is a complex process that regulates protein stability and activity by the sequential actions of E1, E2 and E3 enzymes to influence diverse aspects of eukaryotic cells. However, due to the diversity of proteins in cells, substrate selection is a highly critical part of the process. As a key player in UPS, E3 ubiquitin ligases recruit substrates for ubiquitination specifically. Among them, RING E3 ubiquitin ligases which are the most abundant E3 ubiquitin ligases contribute to diverse cellular processes. The multisubunit cullin‐RING ligases (CRLs) are the largest family of RING E3 ubiquitin ligases with tremendous plasticity in substrate specificity and regulate a vast array of cellular functions. The F‐box protein Skp2 is a component of CRL1 (the prototype of CRLs) which is expressed in many tissues and participates in multiple cellular functions such as cell proliferation, metabolism, and tumorigenesis by contributing to the ubiquitination and subsequent degradation of several specific tumor suppressors. Most importantly, Skp2 plays a pivotal role in a plethora of cancer‐associated signaling pathways. It enhances cell growth, accelerates cell cycle progression, promotes migration and invasion, and inhibits cell apoptosis among others. Hence, targeting Skp2 may represent a novel and attractive strategy for the treatment of different human cancers overexpressing this oncogene. In this review article, we summarized the known roles of Skp2 both in health and disease states in relation to the UPS.

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Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma

Abstract: Our results provide evidence that FBXO45 and FBXO5 may play a key role in tumorigenesis and prognosis of SqCLC.

Cited by 28 publications

References 46 publications

Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers

Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers

FBXO45 is a potential therapeutic target for cancer therapy

Skp2 in the ubiquitin‐proteasome system: A comprehensive review

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