Identification of a ZC3H12D-regulated competing endogenous RNA network for prognosis of lung adenocarcinoma at single-cell level

Chen, Wenhan; Guo, Zaoyang; Wu, Jingyang; Lin, Guang-Tan; Chen, Shaohua; Lin, Qinhui; Yang, Jiansheng; Xu, Yuan; Zeng, Yiming

doi:10.1186/s12885-021-08992-1

Cited by 6 publications

(6 citation statements)

References 74 publications

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“…In hepatocellular carcinoma (HCC), patients with low miR-4443 expression had significantly reduced overall survival [ 12 ]. In breast cancer (BC) [ 33 ] and lung adenocarcinoma (LUAD) [ 41 ], high expression of miR-4443 resulted in decreased overall survival. Upstream regulators of miR-4443 include lncRNA FEZF1-AS1 [ 12 ] and lncRNA ENST0000630242 [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…In breast cancer (BC) [ 33 ] and lung adenocarcinoma (LUAD) [ 41 ], high expression of miR-4443 resulted in decreased overall survival. Upstream regulators of miR-4443 include lncRNA FEZF1-AS1 [ 12 ] and lncRNA ENST0000630242 [ 41 ]. The overall survival rate of HCC patients with high expression of lncRNA FEZF1-AS1 was significantly decreased [ 12 ], while the overall survival rate of LUAD patients with high expression of lncRNA ENST0000630242 was increased [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…Upstream regulators of miR-4443 include lncRNA FEZF1-AS1 [ 12 ] and lncRNA ENST0000630242 [ 41 ]. The overall survival rate of HCC patients with high expression of lncRNA FEZF1-AS1 was significantly decreased [ 12 ], while the overall survival rate of LUAD patients with high expression of lncRNA ENST0000630242 was increased [ 41 ]. Therefore, the difference in the relationship between miR-4443 and the prognosis of patients with different cancers may be related to the existence of different upstream regulators of miR-4443.Due to the limitation of sample type and number of samples, the role of miR-4443 in diagnosis and prognosis needs to be further verified.…”

Section: Discussionmentioning

confidence: 99%

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Aberrant expression of microRNA-4443 (miR-4443) in human diseases

Mao

Shen

et al. 2022

Bioengineered

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miRNA is a small endogenous RNA and an important regulator of gene expression. miR-4443 is abnormally expressed in 12 diseases including cancer. The expression of miR-4443 is regulated by 3 upstream factors. miR-4443 has 12 downstream target genes. miR-4443 inhibits the expression of its target genes, thereby affecting the migration, proliferation, and invasion of pathological cells. miR-4443 participates in 4 signaling pathways and plays a role in the occurrence and development of several diseases. In addition, miR-4443 can also promote resistance to multiple drugs. Here, this article summarizes the aberrant expression of miR-4443 and its pathogenic molecular mechanisms in human diseases, which provides clues and directions for the follow-up research of miR-4443.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Aberrant expression of microRNA-4443 (miR-4443) in human diseases

Mao

Shen

et al. 2022

Bioengineered

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“…In vitro and in vivo assays confirmed that lncRNA Flatr in T cells directly participated in the transcription of Foxp3 as lncRNA Flatr-deficient mice showed delayed induction of Tregs ( 72 ). Besides, high expression of ZC3H12D in Tregs and NSCLC influenced patient prognosis through the ZC3H12D-hsa-miR-4443-ENST00000630242 axis ( 73 ). The highly-expressed membrane and cytoplasmic-localized lnc-INSR aided Tregs formation of an immunosuppressive microenvironment by inducing aberrant activation of the PI3K/AKT pathway in childhood acute T lymphoblastic leukemia ( 74 ).…”

Section: The Ncrna Associated Regulatory Mechanisms Of Tregs In Cancermentioning

confidence: 99%

Non-coding RNA in tumor-infiltrating regulatory T cells formation and associated immunotherapy

Ma,

Xu,

Wang

et al. 2023

Front. Immunol.

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Cancer immunotherapy has exhibited promising antitumor effects in various tumors. Infiltrated regulatory T cells (Tregs) in the tumor microenvironment (TME) restrict protective immune surveillance, impede effective antitumor immune responses, and contribute to the formation of an immunosuppressive microenvironment. Selective depletion or functional attenuation of tumor-infiltrating Tregs, while eliciting effective T-cell responses, represents a potential approach for anti-tumor immunity. Furthermore, it does not disrupt the Treg-dependent immune homeostasis in healthy organs and does not induce autoimmunity. Yet, the shared cell surface molecules and signaling pathways between Tregs and multiple immune cell types pose challenges in this process. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), regulate both cancer and immune cells and thus can potentially improve antitumor responses. Here, we review recent advances in research of tumor-infiltrating Tregs, with a focus on the functional roles of immune checkpoint and inhibitory Tregs receptors and the regulatory mechanisms of ncRNAs in Treg plasticity and functionality.

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“…By blocking the miR-27a-3p/FOXO1 axis, ADAMTS9-AS2 can prevent the proliferation of ccRCC cells and decrease their chemoresistance (Song et al, 2019). Recent research has demonstrated that the CCCH-type zinc finger gene ZC3H12D can influence the prognosis of LUAD patients through influencing mRNA, miRNA, lncRNA, immune cells, and immunological components (Chen et al, 2022). In ccRCC, however, the predictive significance of lncRNA linked with the CCCH type of zinc fingers is unknown.…”

Section: Introductionmentioning

confidence: 99%

A new CCCH-type zinc finger-related lncRNA signature predicts the prognosis of clear cell renal cell carcinoma patients

Shen

Chen²,

Jiang³

et al. 2022

Front. Genet.

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Background: Clear cell renal cell carcinoma (ccRCC) is the main component of renal cell carcinoma (RCC), and advanced ccRCC frequently indicates a poor prognosis. The significance of the CCCH-type zinc finger (CTZF) gene in cancer has been increasingly demonstrated during the past few years. According to studies, targeted radical therapy for cancer treatment may be a revolutionary therapeutic approach. Both lncRNAs and CCCH-type zinc finger genes are essential in ccRCC. However, the predictive role of long non-coding RNA (lncRNA) associated with the CCCH-type zinc finger gene in ccRCC needs further elucidation. This study aims to predict patient prognosis and investigate the immunological profile of ccRCC patients using CCCH-type zinc finger-associated lncRNAs (CTZFLs).Methods: From the Cancer Genome Atlas database, RNA-seq and corresponding clinical and prognostic data of ccRCC patients were downloaded. Univariate and multivariate Cox regression analyses were conducted to acquire CTZFLs for constructing prediction models. The risk model was verified using receiver operating characteristic curve analysis. The Kaplan-Meier method was used to analyze the overall survival (OS) of high-risk and low-risk groups. Multivariate Cox and stratified analyses were used to assess the prognostic value of the predictive feature in the entire cohort and different subgroups. In addition, the relationship between risk scores, immunological status, and treatment response was studied.Results: We constructed a signature consisting of eight CTZFLs (LINC02100, AC002451.1, DBH-AS1, AC105105.3, AL357140.2, LINC00460, DLGAP1-AS2, AL162377.1). The results demonstrated that the prognosis of ccRCC patients was independently predicted by CTZFLs signature and that the prognosis of high-risk groups was poorer than that of the lower group. CTZFLs markers had the highest diagnostic adequacy compared to single clinicopathologic factors, and their AUC (area under the receiver operating characteristic curve) was 0.806. The overall survival of high-risk groups was shorter than that of low-risk groups when patients were divided into groups based on several clinicopathologic factors. There were substantial differences in immunological function, immune cell score, and immune checkpoint expression between high- and low-risk groups. Additionally, Four agents, including ABT737, WIKI4, afuresertib, and GNE 317, were more sensitive in the high-risk group.Conclusion: The Eight-CTZFLs prognostic signature may be a helpful prognostic indicator and may help with medication selection for clear cell renal cell carcinoma.

show abstract

Identification of a ZC3H12D-regulated competing endogenous RNA network for prognosis of lung adenocarcinoma at single-cell level

Cited by 6 publications

References 74 publications

Aberrant expression of microRNA-4443 (miR-4443) in human diseases

Aberrant expression of microRNA-4443 (miR-4443) in human diseases

Non-coding RNA in tumor-infiltrating regulatory T cells formation and associated immunotherapy

A new CCCH-type zinc finger-related lncRNA signature predicts the prognosis of clear cell renal cell carcinoma patients

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