2001
DOI: 10.1093/hmg/10.18.1873
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Identification of a Y chromosome haplogroup associated with reduced sperm counts

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Cited by 86 publications
(69 citation statements)
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References 28 publications
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“…Overall, the difference between the frequencies of the hg K* in the idiopathic infertile males with azoo-/oligozoospermia and the normal control population has been detected in this study, while other haplogroups showed no significant differences. The results were consistent with previously studies in both Danish and Italian populations (Previdere et al 1999;Krausz et al 2001). Although our data showed only Y haplogroup-K* to be associated with a higher predisposition to spermatogenic failure, much more importance should be attached to the role of a Y genetic background in spermatogenesis.…”
Section: Discussionsupporting
confidence: 93%
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“…Overall, the difference between the frequencies of the hg K* in the idiopathic infertile males with azoo-/oligozoospermia and the normal control population has been detected in this study, while other haplogroups showed no significant differences. The results were consistent with previously studies in both Danish and Italian populations (Previdere et al 1999;Krausz et al 2001). Although our data showed only Y haplogroup-K* to be associated with a higher predisposition to spermatogenic failure, much more importance should be attached to the role of a Y genetic background in spermatogenesis.…”
Section: Discussionsupporting
confidence: 93%
“…Related reports have been presented on Italian and Danish populations (Previdere et al 1999;Krausz et al 2001). By performing haplogroup, Krausz et al (2001) identified an European Y haplogroup associated with reduced sperm count and raised the possibility that selection may be indeed active on the Y chromosome in Danish males.…”
Section: Introductionmentioning
confidence: 86%
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“…35 Many recent studies proposed that Y chromosome may have other determining genes for the male phenotype. [36][37][38] A number of diverse phenotypes have been attributed to the Y chromosome, including stature, 39 aggression, 40 handedness, 41 tooth size, 42 cerebral asymmetry, 43 alcohol dependence, 44 high blood pressure, 45 spermatogenic ability, 27,46 and adult height. 47 Researchers have been trying to investigate if there is Y involvement in tumorigenesis of male-specific cancers depending on the fact that the Y chromosome together with prostate and testicular cancers has male-specificity in common.…”
Section: Discussionmentioning
confidence: 99%
“…The Y chromosome plays an important biological role in imparting male characteristics, including sex determination (Sinclair et al, 1990), spermatogenesis (Reijo et al, 1995;Nakahori et al, 1996), and male-specific diseases such as prostate cancer (Stone et al, 1978;Ohnuki et al, 1980;Atkin & Baker, 1985). In addition, there have been reports indicating that there exist associations between Y chromosome haplogroups and male infertility (Kuroki et al, 1999;Krausz et al, 2001;Lu et al, 2007;Yang et al, 2008;Puzuka et al, 2011;Ran et al, 2013;Sato et al, 2013), semen parameters (Sato et al, 2014), and prostate cancer (Ewis et al, 2006;Lindstr€ om et al, 2008;Wang et al, 2012) in some populations, including the Japanese. The Y chromosome haplogroup is also associated with several phenotypes other than male characteristics, including cardiovascular risk (Hiura et al, 2008;Bloomer et al, 2013;Kostrzewa et al, 2013), coronary artery disease (Charchar et al, 2012), lipids (Charchar et al, 2004;Russo et al, 2008), and blood pressure (Charchar et al, 2002).…”
Section: Introductionmentioning
confidence: 99%