1989
DOI: 10.1111/j.1365-2141.1989.tb07711.x
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Identification of a tissue kallikrein in human polymorphonuclear leucocytes

Abstract: We have identified a tissue kallikrein in polymorphonuclear (PMN) leucocytes of normal human blood and bone marrow by immunocytochemistry, radioimmunoassay and enzymology. Immunoreactive tissue kallikrein was visualized in the mature neutrophil leucocytes and in immature forms such as metamyelocytes and myelocytes. No tissue kallikrein was detected in eosinophil leucocytes, lymphocytes, macrophages, megakaryocytes and platelets. So far, we have failed to observe immunoreactivity to tissue kallikrein in basophi… Show more

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Cited by 81 publications
(39 citation statements)
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“…In addition, plasma-derived serine proteases such as kallikrein, plasmin, and thrombin can bind to neutrophils, and their proteolytic activity can be detected on the cell surface (42)(43)(44). Thus, there are several serine esterases that potentially could cleave the plasma membrane DBP binding site.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, plasma-derived serine proteases such as kallikrein, plasmin, and thrombin can bind to neutrophils, and their proteolytic activity can be detected on the cell surface (42)(43)(44). Thus, there are several serine esterases that potentially could cleave the plasma membrane DBP binding site.…”
Section: Resultsmentioning
confidence: 99%
“…Tissue kallikrein has been localized to neutrophils 13 and has been postulated to be involved in neutrophil extravasation through the vascular endothelium and into tissues. Kinin activation of endothelial B 2 receptors has been shown to cause increased intracellular calcium and subsequent endothelial retraction, 14 a critical step in diapedesis.…”
mentioning
confidence: 99%
“…Cell-binding experiments with different components of the kallikrein-kinin system have been performed in situ by immunolocalization [5, or in vitro by binding assays with radiolabeled ligands [6,11]. This study introduces an e~mati~ assay based upon the selective tissue kallikrein substrate H-Pro-Phe-Arg-AMC [lo] to monitor the amidolytic activity of unbound kallikrein using sensitive fluorescence measurements.…”
Section: Resultsmentioning
confidence: 99%