Identification of a Substrain of Himalayan Rabbits Produced in Japan

Matsuo, A.; Kazuta, Hiroki; Kast, A

doi:10.1538/expanim1978.30.3_269

Cited by 11 publications

(7 citation statements)

References 6 publications

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“…In addition, the increase in body weight was significantly large in females (Panel I). Similar findings were observed in white rabbits [5] and Himalayan rabbits [9], however, there is no explanation for this gender difference. In the present study, we assayed serum/plasma biochemical parameters in WHHLMI rabbits, which are important in pharmacological studies and studies of myocardial infarction.…”

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confidence: 74%

Age-Related Changes in Serum/Plasma Biochemical Parameters of WHHLMI Rabbits.

et al. 2004

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Abstract:We developed myocardial infarction-prone rabbits (WHHLMI rabbits) by selectively breeding coronary atherosclerosis-prone WHHL rabbits. To examine the serum/ plasma biochemical parameters of this animal model, we assayed the lipid and glucose levels, and enzyme activities of WHHLMI rabbits from 2 to 26 months of age using solid phase analysis. The results showed a good correlation with those measured with a conventional method. The serum enzyme activities and lipid levels varied with aging despite almost no change in the plasma glucose levels. Gender differences were observed in the total cholesterol, triglyceride, and lactate dehydrogenase activity levels. The data on these serum/plasma biochemical parameters will be useful in studies of myocardial infarction or pharmacological studies using this model. Key words: biochemical parameters, dry chemistry instrument, WHHLMI rabbitsWe have carried out pre-clinical studies of several compounds using WHHL rabbits, which show spontaneous hypercholesterolemia, hyperinsulinemia and atherosclerosis [4,12,15,16,21], to examine whether such compounds can reduce serum lipid levels, ameliorate insulin responses, or suppress atherosclerosis [13-15, 17-19, 22]. Although assays of serum/plasma biochemical parameters are important, there have been no reports on changes in these parameters with aging in this animal model or any other rabbit strain. Recently, we developed an animal model of spontaneous myocardial infarction (WHHLMI rabbit) by selectively breeding coronary atherosclerosis-prone WHHL rabbits [20]. This animal model suffers from myocardial infarction without any interventions and the findings of

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confidence: 74%

Age-Related Changes in Serum/Plasma Biochemical Parameters of WHHLMI Rabbits.

et al. 2004

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“…It has to be assumed that the endpoints described remained constant through these years. To achieve a bett er understanding and assessment, the present dataset is described and compared in parallel with the data from Matsuo e t a l. (1981;Kawanishi, period 1972±1980 ), Lehmann e t a l. (1986;Biberac h, period 1974±1984, Ingelheim 1977±1984, Kawanishi 1972±1984 ) and Matsuo and Kast (1995;Kawanishi, period 1971±1991 ).…”

Section: Resultsmentioning

confidence: 99%

The Himalayan rabbit (Oryctolagus cuniculus L.): spontaneous incidences of endpoints from prenatal developmental toxicity studies

Viertel

Trieb

2003

Lab Anim

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SummaryT he historical database represents the spontaneous, i.e. normal changes of charact ers, in laboratory animals, and is a must for the assessment of toxic effects of compounds. For the Himalayan rabbit (CHBB:HM , SPF) bac kground data were collected from the control groups of regulatory studies between 1968±1999 in the Biberach laboratory of Boehringer Ingelheim (Germany). In the present study these data were compared with the bac kground data from the years 1974±1984, with those from the Ingelheim laboratory, Germany (1977±1984) and those from the breeding colony at Kawanishi, Japan (1971±1991, 1972±1984 ).Fertilit y in the Biberach laboratory was relatively constant through the years, due to the strict breeding system. Litter parameters (corpora lutea, implantations and viabl e fetuses), including fetal sex distribution and fetal weight, were constant in the Biberac h laboratory through the years and compared well with the dat a from Ingelheim and Kawanishi.From these three laborat ories the results of spontaneous changes in fetal morphology above 0.1% incidence suggest a pattern of deviations from the Ba upla n (fundam ental body plan ). T hese comprise synosteosis of sternebrae, lumbar (additional ) ribs, hypoplasia of 12th rib, status of ossi®cation, aplasia of gall bladder, hypoplasia of gal l bladder, incompletely subdivided lung, dilated ventricle of heart, deviat ions at the A. carotis and at the aortic arch and¯exure of paw. T he absence of a time-dependent statistical trend indicates that the spontaneous change of endpoints remained constant through the tim e axis.Comparison with the spontaneously changed fetal morphology of the other strains (NZW, JW, SF rabbits ) does not provide support for their being a totally strain-speci®c pattern, and this pattern may be closer to the species than speci®c to a single strain. T he ®rm patterns of deviat ions in fetal morphology provide suitable and valuable markers for assessing toxic effects on ontogenesis. According to our experience these morphological endpoints react very sensitively to teratogenic compounds, which is dem onstrat ed by increased incidences. Our knowledge of evolution of organisms and of mechanisms leading to morphological deviations points to a strict selection of phenotypes. For laboratory anim als the decisive selection factors are de®ned by man. T hese are nutritive factors, environmental conditions, the mating system , handling and treatm ent, and experimental design. All these factors have to be held constant through the years, which is an absolute pre-condition for the applicati on of valid historical data.T he Himalayan rabbit is highly suitable for use in developmental toxicity studies due to the stability of reproductive data within the same laboratory over a period of more than 30 years, due to the similarity of reproductive data am ong three different laboratories, and due to an absence of relevant differences to the reproductive data of other rabbit strains.

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“…small litter size of Himalayans (5.8-6.9) was rather small compared with all other strains except Silver Fawns (Table 4). There were also marked differences between the 3 Labs keeping the Himalayan rabbits, although the animals originate from the same source [10].…”

Section: Discussionmentioning

confidence: 99%

“…In two previous papers [7,10] the advantages of Himalayan rabbits, the general features of their fertility, reproduction and growth have been reported, and their practical suitability in reproduction toxicology testing, such as higher conception and weaning rate, and lower body weight have been discussed. In their compilation, Kameyama et al [4] have published the teratologic background data of rabbits from various sources in Japan already including some data on Himalayan rabbits.…”

mentioning

confidence: 99%

Litter Parameters and Spontaneous Abnormalities in Himalayan Rabbits

Lehmann

Matsuo

Niggeschulze

et al. 1986

Experimental Animals

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A joint study was undertaken in three testing facilities to evaluate cumulative background data of Himalayan rabbits.All litters were derived from control does. The conception rate was high (84.0-95.1%) but the average numbers of corpora lutea (7.9-8.7), implantation sites (6.5-7.5) and viable fetuses (5.8-6.9) were somewhat lower than that of most other strains of rabbit.Altogether 90 malfomed fetuses (1.12 %) and 425 fetuses with variations (5.270) occurred among 8, 060 virable fetuses.

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Identification of a Substrain of Himalayan Rabbits Produced in Japan

Cited by 11 publications

References 6 publications

Age-Related Changes in Serum/Plasma Biochemical Parameters of WHHLMI Rabbits.

Age-Related Changes in Serum/Plasma Biochemical Parameters of WHHLMI Rabbits.

The Himalayan rabbit (Oryctolagus cuniculus L.): spontaneous incidences of endpoints from prenatal developmental toxicity studies

Litter Parameters and Spontaneous Abnormalities in Himalayan Rabbits

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