Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study

Moia, Lizomar J.M.P.; Matsui, Hideki; Nishio, Hisahide; Tsuchida, Takahiro; Tokuda, Masaaki; Itano, Toshifumi; Nagao, Seigo; Hatase, Osamu

doi:10.1016/0006-8993(92)91219-5

Cited by 2 publications

(1 citation statement)

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“…These kinases have been extensively studied in the field of oncology, and they were originally recognised as products of proto-oncogenes, whose overexpression, mutation and dysregulation in cells can promote the hallmarks of oncogenesis [ 9 ]. In the central nervous system (CNS), six members of SFK (Src, Fyn, Lyn, Lck, Yes and Yrk) have been found [ 10 - 14 ] and they are present in differentiated neurons [ 11 ] and glia including astrocytes [ 15 ], microglial cells [ 16 ], and oligodendrocytes [ 17 ]. SFK are involved in regulating the development and activity of both neuron and glia, neuroplasticity and signal transduction [ 18 , 19 ], suggesting a comprehensive regulatory role of SFK in the CNS.…”

Section: Introductionmentioning

confidence: 99%

Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain

Nie

Chen

et al. 2021

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: Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as a key component in signalling pathways of the central nervous system (CNS) in both physiological and pathological conditions. Despite the crucial role of SFK in signal transduction of the CNS, the relationship between SFK and molecules implicated in pain has been relatively unexplored. This article briefly reviews the recent advances uncovering the interplay of SFK with diverse membrane proteins and intracellular proteins in the CNS and the importance of SFK in the pathophysiology of migraine and neuropathic pain. Mechanisms underlying the role of SFK in these conditions and potential clinical applications of SFK inhibitors in neurological diseases are also summarised. We propose that SFK are the convergent point of signalling pathways in migraine and neuropathic pain and may constitute a promising therapeutic target for these diseases.

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