“…These kinases have been extensively studied in the field of oncology, and they were originally recognised as products of proto-oncogenes, whose overexpression, mutation and dysregulation in cells can promote the hallmarks of oncogenesis [ 9 ]. In the central nervous system (CNS), six members of SFK (Src, Fyn, Lyn, Lck, Yes and Yrk) have been found [ 10 - 14 ] and they are present in differentiated neurons [ 11 ] and glia including astrocytes [ 15 ], microglial cells [ 16 ], and oligodendrocytes [ 17 ]. SFK are involved in regulating the development and activity of both neuron and glia, neuroplasticity and signal transduction [ 18 , 19 ], suggesting a comprehensive regulatory role of SFK in the CNS.…”