1984
DOI: 10.1084/jem.159.1.126
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Identification of a specific interleukin 1 inhibitor in the urine of febrile patients.

Abstract: The urine of febrile patients has been found to contain high concentrations of an inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. The inhibitor is specific for IL-1 and does not block the effects of interleukin 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, and it is not nonspecifically toxic for these cells. IL-1 inhibitor can be found in the urine of normal individuals and afebrile patients, but is present in increased concentrations in the urine of patients with fever of diverse etiolo… Show more

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Cited by 172 publications
(67 citation statements)
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“…4 Its activation induces the release of the soluble IL-1 receptor antagonist that can neutralize the biologic effects of IL-1a and IL-1b. 9,34 IL-1R2 has the same inhibitory effect. 4,35 IL-1R1 ligation signals via the adaptor protein MyD88 to the kinases IRAK-2 and -4 and uses TRAF6 to involve NF-ĸB, p38, Janus kinase, and ERK for initiating the transcription of inflammatory cytokines including pro-IL-1a and pro-IL-1b.…”
Section: Il-1 Receptormentioning
confidence: 49%
“…4 Its activation induces the release of the soluble IL-1 receptor antagonist that can neutralize the biologic effects of IL-1a and IL-1b. 9,34 IL-1R2 has the same inhibitory effect. 4,35 IL-1R1 ligation signals via the adaptor protein MyD88 to the kinases IRAK-2 and -4 and uses TRAF6 to involve NF-ĸB, p38, Janus kinase, and ERK for initiating the transcription of inflammatory cytokines including pro-IL-1a and pro-IL-1b.…”
Section: Il-1 Receptormentioning
confidence: 49%
“…and purified material (13,(14)(15)(16)(17)(18)(19)(20)(21)(22). However, these inhibitors found in vivo did not seem to affect MCF/IL-1 as defined by PGE2 production-stimulating activity (23).…”
Section: Methodsmentioning
confidence: 99%
“…Abbreviations used in this paper: Con A, concanavalin A; DME, Dulbecco's modified Eagles medium; hrIL-l ,B, human recombinant IL-I f,; IL-1, interleukin 1; LAF, lymphocyte-activating factor; MCF, mononuclear cell factor; PGE2, prostaglandin E2-glandin E2 (PGE2) and collagenase, both of which reflect mechanisms of tissue destruction (4)(5)(6)(7)(8). IL-1 has been found in synovial fluid (9,10), serum (11,12), and urine (13,14). However, the control of IL-I activities and its regulation in vivo is poorly understood.…”
Section: Introductionmentioning
confidence: 99%
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“…In vitro, HGP.43 induced cytotoxic activity in macrophages against Lewis carcinoma cells. In vivo, growth of the primary Lewis tumor was not delayed in HGP.43-treated mice, but the size and number of lung metastases were significantly reduced (5 Thymocytes were harvested from C3H/HeJ mice as described by Liao et al (9).…”
mentioning
confidence: 99%