Identification of a single major genetic locus controlling the resistance to lymphocystis disease in Japanese flounder (Paralichthys olivaceus)

Fuji, Kanako; Kobayashi, Kazunobu; Hasegawa, Osamu; Coimbra, Maria Raquel Moura; Sakamoto, Takashi; Okamoto, Nobuaki

doi:10.1016/j.aquaculture.2005.11.024

Cited by 138 publications

(89 citation statements)

References 40 publications

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“…The genetic effects of Atlantic salmon anti-IHN QTLs have been validated in other studies [41]. Fuji et al [42] used a segregated population and located a single major QTL controlling resistance to lymphocystis disease on LG15 in Japanese flounder with a phenotypic variation value of 50%. Further study confirmed that an SSR locus within that QTL was closely related with a phenotype for lymphocystis disease resistance [43].…”

Section: Qtl For Disease Resistancementioning

confidence: 98%

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Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish

Tong

Sun

2015

Sci. China Life Sci.

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The traits of cultured fish must continually be genetically improved to supply high-quality animal protein for human consumption. Economically important fish traits are controlled by multiple gene quantitative trait loci (QTL), most of which have minor effects, but a few genes may have major effects useful for molecular breeding. In this review, we chose relevant studies on some of the most intensively cultured fish and concisely summarize progress on identifying and verifying QTLs for such traits as growth, disease and stress resistance and sex in recent decades. The potential applications of these major-effect genes and their associated markers in marker-assisted selection and molecular breeding, as well as future research directions are also discussed. These genetic and genomic analyses will be valuable for elucidating the mechanisms modulating economically important traits and to establish more effective molecular breeding techniques in fish.aquaculture fish, economic traits, QTL, major genes, molecular markers, molecular breeding Citation:Tong JG, Sun XW. Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish. Sci

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Section: Qtl For Disease Resistancementioning

confidence: 98%

“…Fuji et al [42] found an SSR allele associated with IPN, and used it during large-scale anti-IPN selective breeding and fingerling production [43]. Selective breeding of gibeio carp has made good progress using anti-myxosporean-related MHC alleles as molecular markers [79].…”

Section: Progress Of Applied Molecular Breeding Studiesmentioning

confidence: 99%

Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish

Tong

Sun

2015

Sci. China Life Sci.

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“…And as such, diferent approaches such as SNP, MTLS, AFLP, RAPD, RFLP and QTL analyses have been used for the identiication of disease resistance and susceptibility traits in diferent aquatic organisms. In the case of ish viral diseases, QTL resistance traits have been generated for grass cap reovirus (GCRV) infection in grass carp [179], nervous necrosis virus (NNV) in seabass [180], viral hemorrhagic septicemia (VHS) in turbot [181] and rainbow trout [182], infectious salmon anaemia (ISAV) virus in Atlantic salmon, lymphocytic disease virus in Japanese lounder [183] and infectious pancreatic necrosis virus (IPNV) in Atlantic salmon [184,185]. Among these, the QTL for resistance against IPNV has contributed to signiicantly reducing the IPNV incidence by >80% from 2008 when IPNV resistance ish were introduced in the Norwegian Atlantic salmon industry to 2015 [186].…”

Section: Applications Of Rna-seq and Omics Strategies -From Microorgamentioning

confidence: 99%

Current Advances in Functional Genomics in Aquaculture

Munang’andu¹,

Evensen²

2017

Applications of RNA-Seq and Omics Strategies - From Microorganisms to Human Health

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Gene expression studies in aquaculture have slowly evolved from the traditional reductionist approach of single gene sequencing to high throughput sequencing (HTS) techniques able to sequence entire genomes of living organisms. The upcoming of HTS techniques has led to emergence of metagenomics, nutrigenomics, epigenetics and other omics technologies in aquaculture in the last decade. Metagenomics analyses have accelerated the speed at which emerging pathogens are being discovered, thereby contributing to the design of timely disease control strategies in aquaculture. Using metagenomics, it is easy to identify and monitor microbial communities found in diferent ecosystems. In vaccine production, genomic studies are being used to identify cross neutralizing antigens against variant strains of the same pathogens. In genetics and epigenetics, genomics traits have been identiied that are beginning to gain commercial applications in aquaculture. Nutrigenomics have not only enhanced our understanding of the biological markers for nutrition-related diseases, but they have also enhanced our ability to formulate diets able to maintain a stable immune homeostasis in the gut. Overall, herein, we have shown that functional genomics provide multifaceted applications ranging from monitoring microbial communities in aquatic environments to optimizing production systems in aquaculture.

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“…In the tongue sole, a female-specific DNA marker, located in the sex-linked LG5 (Liao et al 2009), has also been identified (Chen et al 2007). Regarding disease resistance, Aeromonas salmonicida resistance-related traits and a major locus on LG15 (marker Poli.9-8TUF) for resistance to lymphocystis disease have been reported in turbot (Rodríguez-Ramilo et al 2011) and Japanese flounder (Fuji et al 2006(Fuji et al , 2007, respectively. The latter trait in Japanese flounder has been successfully applied as a selection breeding marker.…”

Section: Genetic Maps and Detection Of Quantitative Trait Loci (Qtls)mentioning

confidence: 99%

Advances in genomics for flatfish aquaculture

Cerdà

Manchado

2012

Genes Nutr

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Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of high commercial interest because of their highly prized white flesh. However, the aquaculture of these fishes is seriously hampered by the scarce knowledge on their biology. In recent years, various experimental 'omics' approaches have been applied to farmed flatfishes to increment the genomic resources available. These tools are beginning to identify genetic markers associated with traits of commercial interest, and to unravel the molecular basis of different physiological processes. This article summarizes recent advances in flatfish genomics research in Europe. We focus on the new generation sequencing technologies, which can produce a massive amount of DNA sequencing data, and discuss their potentials and applications for de novo genome sequencing and transcriptome analysis. The relevance of these methods in nutrigenomics and foodomics approaches for the production of healthy animals, as well as high quality and safety products for the consumer, is also briefly discussed.

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Identification of a single major genetic locus controlling the resistance to lymphocystis disease in Japanese flounder (Paralichthys olivaceus)

Cited by 138 publications

References 40 publications

Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish

Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish

Current Advances in Functional Genomics in Aquaculture

Advances in genomics for flatfish aquaculture

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