Identification of a sildenafil analogue adulterated in two herbal food supplements

Lin, Mei-Chih; Liu, Yi-Chu; Lin, Jer-Huei

doi:10.38212/2224-6614.2479

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…A survey conducted in 2006 in China established the content of the sildenafil analogue in two food supplements for erectile dysfunction [ 23 ]. Its structure was similar to that of sildenafil with a single difference in the piperazine part where N-CH 3 was substituted with N-CH 2 CH 2 OH.…”

Section: Introductionmentioning

confidence: 99%

Survey on Sildenafil, Tadalafil, and Vardenafil Concentrations in Food Supplements for Erectile Dysfunction

Petkova-Gueorguieva

Gueorguiev

Lebanova

et al. 2022

International Journal of Analytical Chemistry

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The aim of the study was to analyze the presence of undeclared sildenafil, tadalafil, and vardenafil in food supplements (FSs) for erectile dysfunction. The presence of sildenafil, tadalafil, and vardenafil was determined using the generated ultraviolet (UV)-spectra and mass-spectrometry (MS)-spectra as well as chromatograms produced by the photodiode array (PDA)-detector and ion trap MS-detector. The results were processed by Xcalibur ver. 2.0.7. Fourteen of the 20 analyzed FSs contained undeclared ingredients. Sildenafil was present in 12 of them. Many violations and discrepancies between the label information and the real composition of the FS were identified. 70% of the samples contained undeclared ingredients of an erectile dysfunction medicinal product. The quantities varied within broad limits from 2 mg per tablet to 116.55 mg per tablet. Sildenafil was present in amounts exceeding 16.55 mg that is the maximum recommended dose, thus creating risk of overdose. Besides that, food supplements adulterated with sildenafil analogues are a health risk for consumer’s health as there is no evidence of modified sildenafil toxicity. All analyzed FSs were claimed to be 100% natural, not provoking side effects. No information for any FS contained indications of age limits or risk for interaction with other FSs or medical products.

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Section: Introductionmentioning

confidence: 99%

Survey on Sildenafil, Tadalafil, and Vardenafil Concentrations in Food Supplements for Erectile Dysfunction

Petkova-Gueorguieva

Gueorguiev

Lebanova

et al. 2022

International Journal of Analytical Chemistry

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“…Limit of Detection (LOD) and Quantification (LOQ) of the method were tested in the range of: 20 -200 ng µL-1 sildenafil. The results were: 0.23 ng and 0.68 ng for LOD and LOQ, respectively (9.2 ng µL-1 and 27.2 ng mL-1 for LOD and LOQ, respectively, obtained with 25 µL injected) [10,11]. Selectivity of the method was proved with the chromatographic peak resolution obtained between sildenafil and tadanafil (Rs = 10, 5) (Figures 4-5) and the characteristic UV-spectrum.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of sildenafil citrate validated HPLC method and its pharmaceutical dosage forms

Pathy¹

2018

OMCIJ

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The process is from the penultimate intermediate namely 5-(5-chlorosulphonyl-2-ethoxy phenyl) -1-methyl-3-N-propyl-1,6-dihydro-7H-pyrasolo-(4,3-d)pyrimidin-7-one, which is herein will be referred to as chlorosulphonyl intermediate ( 21). This intermediate is condensed with N-methylpiperazine (2) in a solvent preferably of chlorinated hydrocarbon in presence of a trisubstituted amine or in presence of mixture of such amines (Figure 3) [2].

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Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs

Singh

Prasad

Savaliya

et al. 2009

TrAC Trends in Analytical Chemistry

152

109

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Identification of a sildenafil analogue adulterated in two herbal food supplements

Cited by 3 publications

References 5 publications

Survey on Sildenafil, Tadalafil, and Vardenafil Concentrations in Food Supplements for Erectile Dysfunction

Survey on Sildenafil, Tadalafil, and Vardenafil Concentrations in Food Supplements for Erectile Dysfunction

Synthesis of sildenafil citrate validated HPLC method and its pharmaceutical dosage forms

Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs

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