Identification of a set of genes with developmentally down-regulated expression in the mouse brain

Kumar, Sharad; Tomooka, Yasuhiro; Noda, Makoto

doi:10.1016/0006-291x(92)91747-e

Cited by 500 publications

(346 citation statements)

References 15 publications

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“…1,2 Given the function of caspase-1 (IL-1b-converting enzyme) in IL-1b maturation, caspase-2 was hailed as the caspase that was more likely to functionally emulate CED-3 in mammalian cell death. 3,4 However, as we now know, there are about a dozen caspases in mammals, some with distinct functions in cell death and/or inflammation.…”

Section: Open Questionsmentioning

confidence: 99%

Caspase-2 as a tumour suppressor

2013

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Ever since its discovery 20 years ago, caspase-2 has been enigmatic and its function somewhat controversial. Although many in vitro studies suggested that caspase-2 was important for apoptosis, demonstrating an in vivo cell death role for this caspase has been more problematic, with caspase-2-deficient mice showing limited, tissue-specific cell death defects. Recent results from different laboratories suggest that at least one of its physiological roles in animals is to protect against cellular stress and transformation. As such, loss of caspase-2 augments tumorigenesis in some mouse models of cancer, assigning a tumour suppressor function to this enigmatic caspase. This review focuses on this seemingly non-apoptotic function of caspase-2 as a tumour suppressor and reconciles some of the recent findings in the field.

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Section: Open Questionsmentioning

confidence: 99%

Caspase-2 as a tumour suppressor

2013

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“…One of the ubiquitously expressed and most evolutionarily conserved mammalian caspase is caspase-2 (Kumar et al, 1992(Kumar et al, , 1994Wang et al, 1994;Lamkanfi et al, 2002). It is also one of the closest mammalian homologues of the Caenorhabditis elegans CED-3, the first-discovered caspase (Kumar et al, 1992(Kumar et al, , 1994Yuan et al, 1993;Wang et al, 1994;Lamkanfi et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Despite its conservation and discovery as one of the first mammalian homologues of CED-3, the physiological function of caspase-2 remains controversial. Like CED-3 in C. elegans (Yuan et al, 1993), the initiator caspase DRONC in Drosophila and caspase-9 in mammals, caspase-2 contains a caspase recruitment domain (CARD) (Kumar et al, 1992;Dorstyn et al, 1999;Kumar and Doumanis, 2000;Degterev et al, 2003;Kumar, 2007). Caspase-2 activation occurs rapidly in response to diverse apoptotic signals in most cell types (Harvey et al, 1997;Zhivotovsky and Orrenius, 2005;Kumar, 2007).…”

Section: Introductionmentioning

confidence: 99%

Caspase-2 is required for cell death induced by cytoskeletal disruption

et al. 2008

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“…D42055) (Nagase et al 1995). Nedd4 was initially cloned by a subtraction approach as a transcript highly expressed in the mouse embryonic brain, and down-regulated during development (Kumar et al 1992). At present, Nedd4 is known to be a unique protein containing an N-terminal calcium-dependent lipid binding domain (C2) (Newton 1995), specific protein-protein interaction (WW) (Sudol et al 1995a,b), and Hect domain in the Cterminal region.…”

Section: Introductionmentioning

confidence: 99%