Identification of a retinoic acid-inducible gene I from Japanese eel (Anguilla japonica) and expression analysis in vivo and in vitro

Feng, Jia; Guo, Songlin; Lin, Peng; Wang, Yilei; Zhang, Ziping; Zhang, Zaipeng; Yu, Lili

doi:10.1016/j.fsi.2016.05.036

Cited by 13 publications

(5 citation statements)

References 42 publications

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“…In as much as PGC1α is regulated by Foxo1, enhanced Foxo1 activation (through the inhibition of mTORC2) can promote the generation of memory CD8 + T cells [18,46]. Pharmacologically or genetically enhancing PGC1α represents a potential strategy for enhancing the robustness of T cell responses.…”

Section: Altering the Mitochondriamentioning

confidence: 99%

Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease

Patel

Powell

2017

Current Opinion in Immunology

100

107

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Summary It is becoming increasingly clear that metabolic reprogramming plays a critical role in T cell activation, differentiation and function. To this end, cellular metabolism not only meets the energetic demands of T cells but also provides critical substrates for their growth and function. Furthermore, metabolites themselves are emerging as key regulators of immune responses. As the details of how metabolic reprogramming regulates immune function are revealed, new potential targets for modulating immune responses have emerged. Indeed, the distinct metabolic demands of different T cell subsets make them exquisitely sensitive to pharmacologic inhibitors of metabolism. In this review, we will describe the emerging strategies whereby targeting metabolism can shape the T cell response.

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Section: Altering the Mitochondriamentioning

confidence: 99%

Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease

Patel

Powell

2017

Current Opinion in Immunology

100

107

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“…Teleosts were used in several studies to investigate the structures, signaling pathways, and antipathogen functions of NOD2 and RIG-I [23,24,25,26,27,28,29,30,31,32,33,34,35]. Extensive related studies have been conducted using zebrafish, and the results indicated that Dr NOD2 and Dr RIG-I were highly conserved and similar to their mammalian counterparts [36,37,38].…”

Section: Introductionmentioning

confidence: 99%

Mutual Regulation of NOD2 and RIG-I in Zebrafish Provides Insights into the Coordination between Innate Antibacterial and Antiviral Signaling Pathways

Nie

Xiang

et al. 2017

IJMS

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Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and retinoic acid-inducible gene I (RIG-I) are two important cytosolic pattern recognition receptors (PRRs) in the recognition of pathogen-associated molecular patterns (PAMPs), initiating innate antibacterial and antiviral signaling pathways. However, the relationship between these PRRs, especially in teleost fish models, is rarely reported. In this article, we describe the mutual regulation of zebrafish NOD2 (DrNOD2) and RIG-I (DrRIG-I) in innate immune responses. Luciferase assays were conducted to determine the activation of NF-κB and interferon signaling. Morpholino-mediated knockdown and mRNA-mediated rescue were performed to further confirm the regulatory roles between DrNOD2 and DrRIG-I. Results showed that DrNOD2 and DrRIG-I shared conserved structural hallmarks with their mammalian counterparts, and activated DrRIG-I signaling can induce DrNOD2 production. Surprisingly, DrNOD2-initiated signaling can also induce DrRIG-I expression, indicating that a mutual regulatory mechanism may exist between them. Studies conducted using HEK293T cells and zebrafish embryos showed that DrRIG-I could negatively regulate DrNOD2-activated NF-κB signaling, and DrNOD2 could inhibit DrRIG-I-induced IFN signaling. Moreover, knocking down DrRIG-I expression by morpholino could enhance DrNOD2-initiated NF-κB activation, and vice versa, which could be rescued by their corresponding mRNAs. Results revealed a mutual feedback regulatory mechanism underlying NOD2 and RIG-I signaling pathways in teleosts. This mechanism reflects the coordination between cytosolic antibacterial and antiviral PRRs in the complex network of innate immunity.

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“…In addition, studies in mammals have reported that Aeromonas is capable of causing ocular infection leading to inflammation and abscesses [60,61]. Notably, several antiviral-related genes (irf3, mda5, and rig-i) have been identified as key players in antimicrobial immune responses and the maintenance of microbial homeostasis [62][63][64]. Therefore, Aeromonas may contribute significantly to the proinflammatory response observed in trout OM at 4 DPI after IHNV infection.…”

Section: Discussionmentioning

confidence: 99%

Ocular mucosal homeostasis of teleost fish provides insight into the coevolution between microbiome and mucosal immunity

Kong,

Cheng,

Cao

et al. 2024

Microbiome

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Background The visual organ plays a crucial role in sensing environmental information. However, its mucosal surfaces are constantly exposed to selective pressures from aquatic or airborne pathogens and microbial communities. Although few studies have characterized the conjunctival-associated lymphoid tissue (CALT) in the ocular mucosa (OM) of birds and mammals, little is known regarding the evolutionary origins and functions of immune defense and microbiota homeostasis of the OM in the early vertebrates. Results Our study characterized the structure of the OM microbial ecosystem in rainbow trout (Oncorhynchus mykiss) and confirmed for the first time the presence of a diffuse mucosal-associated lymphoid tissue (MALT) in fish OM. Moreover, the microbial communities residing on the ocular mucosal surface contribute to shaping its immune environment. Interestingly, following IHNV infection, we observed robust immune responses, significant tissue damage, and microbial dysbiosis in the trout OM, particularly in the fornix conjunctiva (FC), which is characterized by the increase of pathobionts and a reduction of beneficial taxa in the relative abundance in OM. Critically, we identified a significant correlation between viral-induced immune responses and microbiome homeostasis in the OM, underscoring its key role in mucosal immunity and microbiota homeostasis. Conclusions Our findings suggest that immune defense and microbiota homeostasis in OM occurred concurrently in early vertebrate species, shedding light on the coevolution between microbiota and mucosal immunity.

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Identification of a retinoic acid-inducible gene I from Japanese eel (Anguilla japonica) and expression analysis in vivo and in vitro

Cited by 13 publications

References 42 publications

Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease

Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease

Mutual Regulation of NOD2 and RIG-I in Zebrafish Provides Insights into the Coordination between Innate Antibacterial and Antiviral Signaling Pathways

Ocular mucosal homeostasis of teleost fish provides insight into the coevolution between microbiome and mucosal immunity

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