Identification of a rearrangement in the 5' upstream region of the poly(ADP-ribose) polymerase pseudogene on chromosome 13 in Ewing's sarcoma cells

Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following γ-irradiation

“…Bcl-2-expression has been shown previously to protect human B cells from other apoptotic stimuli, including growth/ survival factor withdrawal, antigen receptor crosslinking and Ca 2+ -ionophore treatment Holder et al, 1993;Milner et al, 1992Milner et al, , 1993Wang et al, 1996). Bcl-2 has also been shown to repress apoptosis in response to DNA damage in a variety of systems (Collins et 1996; Sentman et al, 1991;Strasser et al, 1994;Soldatenkov et al, 1996). Interestingly, we noted that the presence of Bcl-2 was not su cient to maintain prolonged resistance to apoptosis and all three Bcl-2 transfectants showed evidence of increased apoptosis by one week after irradiation, with one cell line (CHEP/Bcl-2) showing a markedly high level (up to 60%).…”

“…Exogenous growth/survival factors, such as IFN-g, IL-2, IL-3, IL-4 and IL-7 suppress DNA-damage-induced apoptosis (Canman et al, 1995;Collins et al, 1992;Sangfelt et al, 1996;Seki et al, 1995). Constitutive expression of bcl-2, the prototype survival gene, also promotes survival of cells exposed to radiation and other DNAdamaging agents (Collins et al, 1992;Gilbert et al, 1996;Kyprianou et al, 1997;Lock and Stribinskiene, 1996;Sentman et al, 1991;Strasser et al, 1994;Soldatenkov et al, 1996).…”