Identification of a pyrovalerone metabolite in the rat by gas chromatography-mass spectrometry and determination of pyrovalerone by gas chromatography-nitrogen-phosphorus detection

Spectroscopic characterization of 3,4-methylenedioxypyrrolidinobutyrophenone: A new designer drug with α-pyrrolidinophenone structure

“…1 documents the ongoing development of designer drugs with an a-pyrrolidinophenone structure. The a-pyrrolidinophenones are structurally closely related to the central stimulatory 1-phenyl-2-pyrrolidinopentane (PPP, prolintane) [9], cathinone, methcathinone, and other a-aminophenones [10][11][12][13][14][15].…”

Mass spectral and NMR spectral data of two new designer drugs with an α-aminophenone structure: 4′-Methyl-α-pyrrolidinohexanophenone and 4′-methyl-α-pyrrolidinobutyrophenone

“…1). These compounds are closely related to the central stimulating 1-phenyl-pyrrolidino-pentane (prolintane) [1] and aaminophenones like cathinone, methcathinone, 2-methylamino-1-phenylpropane-1-one (Jeff) [2], bupropion [3], amfepramone, metamfepramone, 3,4-methylenedioxycathinone homologs [4] or 4 0 -methyl-a-pyrrolidinovalerophenone (pyrovalerone) [5][6][7][8]. Information about the dosage [1], pharmacology [1,5] and toxicology [1,3] is available only for some of these compounds.…”

“…The metabolism of pyrovalerone, PPP, MPPP, MOPPP, MDPPP, and MPHP in rats as well as of bupropion has been described in literature [3,[7][8][9][10][11][12][13].…”

Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MPDV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time‐of‐flight mass spectrometry

“…MDPV has been characterized by NMR and mass spectrometry in samples obtained from confiscation 6,7 and the metabolism of drugs with similar structures has been studied in rats. [8][9][10][11][12][13][14] Because of regulations and Italian law, it was not possible to assess the metabolism and excretion of MDPV in humans. The aims of this study were to develop an analytical method for the screening of MDPV in biological fluids and to study its phase I and II metabolism by in vitro assays employing human liver microsomes and S9 cellular fractions.…”