Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor

Xiao, Xiaodong; Feng, Yang; Zhu, Zhongyu; Dimitrov, Dimiter S.

doi:10.1016/j.bbrc.2011.06.109

Cited by 82 publications

(62 citation statements)

References 28 publications

(30 reference statements)

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“…The cellular receptor for CCHFV has not been identified, but a recent study employing the soluble ectodomains of G N and G C suggested that G C plays the major role in binding to target cells, and identified the host molecule nucleolin as essential for cell entry (Xiao et al, 2011). The virus appears to enter host cells by clathrin-dependent endocytosis (Fig.…”

Section: Replication Cyclementioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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Bente, Dennis A.; Forrester, Naomi L.; Watts, Douglas M.; McAuley, Alexander J.; Whitehouse, Chris A.; and Bray, Mike, "CrimeanCongo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity" (2013 b s t r a c tCrimean-Congo hemorrhagic fever (CCHF) is the most important tick-borne viral disease of humans, causing sporadic cases or outbreaks of severe illness across a huge geographic area, from western China to the Middle East and southeastern Europe and throughout most of Africa. CCHFV is maintained in vertical and horizontal transmission cycles involving ixodid ticks and a variety of wild and domestic vertebrates, which do not show signs of illness. The virus circulates in a number of tick genera, but Hyalomma ticks are the principal source of human infection, probably because both immature and adult forms actively seek hosts for the blood meals required at each stage of maturation. CCHF occurs most frequently among agricultural workers following the bite of an infected tick, and to a lesser extent among slaughterhouse workers exposed to the blood and tissues of infected livestock and medical personnel through contact with the body fluids of infected patients. CCHFV is the most genetically diverse of the arboviruses, with nucleotide sequence differences among isolates ranging from 20% for the viral S segment to 31% for the M segment. Viruses with diverse sequences can be found within the same geographic area, while closely related viruses have been isolated in far distant regions, suggesting that widespread dispersion of CCHFV has occurred at times in the past, possibly by ticks carried on migratory birds or through the international livestock trade. Reassortment among genome segments during co-infection of ticks or vertebrates appears to have played an important role in generating diversity, and represents a potential future source of novel viruses. In this article, we first review current knowledge of CCHFV, summarizing its molecular biology, maintenance and transmission, epidemiology and geographic range. We also include an extensive discussion of CCHFV genetic diversity, including maps of the range of the virus with superimposed phylogenetic trees. We then review the features of CCHF, including the clinical syndrome, diagnosis, treatment, pathogenesis, vaccine development and laboratory animal models of CCHF. The paper ends with a discussion of the possible future geographic range of the virus. For the benefit of researchers, we include a Supplementary Table listing all published reports of CCHF cases and outbreaks in the English-language literature, plus some principal articles in other languages, with total case numbers, case fatality rates and all CCHFV strains on GenBank.

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Section: Replication Cyclementioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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“…69 Nucleolin is also believed to participate in the infection of Hepatitis C virus (HCV), herpes simplex virus (HSV) type 1, white-spot syndrome virus (WSSV) and the Crimean-Congo hemorrhagic fever virus (CCHFV). [70][71][72][73] Interestingly, nucleolin forms RNP complexes with the 3' UTR of feline calicivirus (FCV) and Norwalk virus (NV); in this regard, lowering nucleolin reduced viral protein synthesis and FCV replication, while the mobilization of nucleolin from the nucleolus to the perinuclear region was proposed to enhance viral mRNA translation. 74 The association of nucleolin with the 5' UTR IRES of rhinovirus and poliovirus stimulated the translation of viral proteins in vitro and in vivo.…”

Section: Nucleolin Target Transcriptsmentioning

confidence: 99%

RNA-binding protein nucleolin in disease

2012

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“…NCL is involved in attachment or entry of several unrelated viruses, including human parainfluenza virus type 3, respiratory syncytial virus, Crimean-Congo hemorrhagic fever virus, Japanese encephalitis virus (JEV), and HIV (41)(42)(43)(44)(45)(46)(47). NCL colocalizes with hepatitis D virus delta antigen and interacts with herpes simplex virus 1 protein US11, cytomegalovirus UL44, white-spot syndrome virus VP15, influenza virus (H3N2) NS1, and the NS5B protein of hepatitis C virus.…”

mentioning

confidence: 99%

Nucleolin Interacts with the Dengue Virus Capsid Protein and Plays a Role in Formation of Infectious Virus Particles

Balinsky

Schmeisser

Ganesan

et al. 2013

J Virol

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Dengue virus (DENV), a member of the genus Flavivirus, causes a spectrum of disease in humans that can range from a mild febrile illness to potentially fatal hemorrhage or shock syndromes. Four serotypes of DENV (DENV-1, -2, -3, and -4) are transmitted by the bite of a mosquito vector and are responsible for more than 50 million infections each year. Infection with one DENV serotype does not confer lasting immunity to the others (1-3). The most severe clinical manifestations of dengue are associated with secondary infections by a heterologous DENV serotype (2). Increasing urbanization, cocirculation of multiple DENV serotypes within the same geographic area, and expansion of its insect vector contribute to the increasing importance of dengue to global health (2, 3).DENV contains a positive-sense single-stranded RNA (ssRNA) genome that is translated as a single open reading frame. The resulting polyprotein is cleaved by virus and host proteases into three structural and at least seven nonstructural proteins (4, 5). The capsid (C) protein functions as a structural component of the DENV virion, encapsulating the ssRNA genome of the virus (4, 5). The DENV C protein is composed of four alpha helices with an unstructured amino terminus and forms antiparallel homodimers.

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Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor

Cited by 82 publications

References 28 publications

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

RNA-binding protein nucleolin in disease

Nucleolin Interacts with the Dengue Virus Capsid Protein and Plays a Role in Formation of Infectious Virus Particles

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