2016
DOI: 10.1016/j.jid.2016.06.623
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Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue

Abstract: first year that cutaneous warts on the hands were assessed, were included in this analysis (Melski et al., 1977; Stern et al., 1979). The Mann-Whitney (Wilcoxon) twosample test for medians and Student t test for means were used to test for statistical significant differences between groups. Poisson regression was used to calculate the association of developing subsequent SCCs or BCCs with the presence of cutaneous hand warts in 1985e1986 and other risk factors. Age, sex, geographic location, and population inc… Show more

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Cited by 14 publications
(11 citation statements)
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“…By contrast, lesions with JSS 2015 scores of 16 points or more have strong keloid properties and tend to resist treatment. Thus, the JSS 2015 classification appears to reflect clinical reality.Biomarkers that can clearly distinguish keloids from hypertrophic scars have not yet been found, despite the many studies that have searched for them [6]. Systemic factors can influence keloid and hypertrophic scar progression: both lesion forms are known to worsen in pregnant women [7, 8] and in patients with hypertension [9].…”
Section: Main Contextmentioning
confidence: 99%
“…By contrast, lesions with JSS 2015 scores of 16 points or more have strong keloid properties and tend to resist treatment. Thus, the JSS 2015 classification appears to reflect clinical reality.Biomarkers that can clearly distinguish keloids from hypertrophic scars have not yet been found, despite the many studies that have searched for them [6]. Systemic factors can influence keloid and hypertrophic scar progression: both lesion forms are known to worsen in pregnant women [7, 8] and in patients with hypertension [9].…”
Section: Main Contextmentioning
confidence: 99%
“…37 One other overexpressed immune molecule in keloid scar tissue is syndecan-1 (CD138), identified as one of the potential biomarkers for keloid disease diagnosis. 38 Several in vitro studies have explored the stimulation of certain cytokines on KFs in monolayer cultures. 39,40 For instance, connective tissue growth factor (CTGF), was demonstrated to be involved in intracellular signaling pathways in KFs.…”
Section: Two-dimensional Monolayer Culture Modelsmentioning
confidence: 99%
“…Its levels are raised in fibrotic dermis, due to the induction of TGFβ and the insulin-like growth factor binding protein-3 (IGFBP-3) [195]. Syndecan-1 is also overexpressed in keloid scars compared to normal or hypertrophic scars [196].…”
Section: Syndecansmentioning
confidence: 99%