Identification of a potent PCNA‐p15‐interaction inhibitor by autodisplay‐based peptide library screening
Sarah Hardebeck,
Natalie Jácobo Goebbels,
Caroline Michalski
et al.
Abstract:Proliferating cell nuclear antigen (PCNA) is an essential factor for DNA metabolism. The influence of PCNA on DNA replication and repair, combined with the high expression rate of PCNA in various tumours renders PCNA a promising target for cancer therapy. In this context, an autodisplay‐based screening method was developed to identify peptidic PCNA interaction inhibitors. A 12‐mer randomized peptide library consisting of 2.54 × 106 colony‐forming units was constructed and displayed at the surface of Escherichi… Show more
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