Identification of a population of peripheral sensory neurons that regulates blood pressure

Morelli, Chiara; Castaldi, Laura; Brown, Sam J.; Streich, Lina; Websdale, Alexander; Taberner, Francisco J.; Cerreti, Blanka; Barenghi, Alessandro; Blum, Kevin M.; Sawitzke, Julie; Frank, Tessa; Doleschall, Balint; Serrao, Joana; Ferrarini, Denise; Lechner, Stefan; Prevedel, Robert; Heppenstall, Paul A.

doi:10.1016/j.celrep.2021.109191

Cited by 19 publications

(18 citation statements)

References 58 publications

(82 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3f,g). Sensory modulation of sympathetic activity has been documented in other organs 39,40 at the spinal or supraspinal levels [41][42][43] . We did not observe a significant change in total noradrenaline content in sensory-ablated fat (Extended Data Fig.…”

Section: Discussionmentioning

confidence: 99%

The role of somatosensory innervation of adipose tissues

Wang

Leung

Zhang

et al. 2022

Nature

View full text Add to dashboard Cite

Adipose tissues communicate with the central nervous system to maintain whole-body energy homeostasis. The mainstream view is that circulating hormones secreted by the fat convey the metabolic state to the brain, which integrates peripheral information and regulates adipocyte function through noradrenergic sympathetic output1. Moreover, somatosensory neurons of the dorsal root ganglia innervate adipose tissue2. However, the lack of genetic tools to selectively target these neurons has limited understanding of their physiological importance. Here we developed viral, genetic and imaging strategies to manipulate sensory nerves in an organ-specific manner in mice. This enabled us to visualize the entire axonal projection of dorsal root ganglia from the soma to subcutaneous adipocytes, establishing the anatomical underpinnings of adipose sensory innervation. Functionally, selective sensory ablation in adipose tissue enhanced the lipogenic and thermogenetic transcriptional programs, resulting in an enlarged fat pad, enrichment of beige adipocytes and elevated body temperature under thermoneutral conditions. The sensory-ablation-induced phenotypes required intact sympathetic function. We postulate that beige-fat-innervating sensory neurons modulate adipocyte function by acting as a brake on the sympathetic system. These results reveal an important role of the innervation by dorsal root ganglia of adipose tissues, and could enable future studies to examine the role of sensory innervation of disparate interoceptive systems.

show abstract

Section: Discussionmentioning

confidence: 99%

The role of somatosensory innervation of adipose tissues

Wang

Leung

Zhang

et al. 2022

Nature

View full text Add to dashboard Cite

show abstract

“…There is direct anatomical communication between DRG and the paravertebral sympathetic chain [14]. DRG mechanosensitive neurons projecting to distal blood vessels seem to play a major role in cardiovascular autonomic regulation [15]. Satellite glial cells not only encase DRG neuron cell bodies but also neurons lying in sympathetic and parasympathetic ganglia [16].…”

mentioning

confidence: 99%

Is fibromyalgia an autoimmune illness?

Martı́nez-Lavı́n

2021

Clin Rheumatol

View full text Add to dashboard Cite

“…In dorsal root ganglia (DRG) 15–30% of neurons express TH, depending on their vertebral level, and distinguish c-fiber low threshold mechanoreceptors (c-LTMRs) and small diameter neurons that innervate blood vessels and regulate blood pressure ( Price and Mudge, 1983 ; Brumovsky et al, 2006 , 2012 ; Li et al, 2011 ; Morelli et al, 2021 ). Because c-LTMRs respond to light, affective touch, we wondered whether recently-identified Ret -expressing mechanoreceptors in the GG ( Donnelly et al, 2018 ) could be c-LTMRs and communicate pleasurable or aversive food textures.…”

Section: Resultsmentioning

confidence: 99%

Oral Sensory Neurons of the Geniculate Ganglion That Express Tyrosine Hydroxylase Comprise a Subpopulation That Contacts Type II and Type III Taste Bud Cells

Tang

Pierchala

2022

eNeuro

View full text Add to dashboard Cite

Oral sensory neurons of the geniculate ganglion (GG) innervate taste papillae and buds on the tongue and soft palate. Electrophysiological recordings of these neurons and fibers revealed complexity in the number of unique response profiles observed, suggesting there are several distinct neuronal subtypes. Molecular descriptions of these subpopulations are incomplete. We report here the identification of a subpopulation of GG oral sensory neurons in mice by expression of tyrosine hydroxylase (TH). TH-expressing geniculate neurons represent 10–20% of oral sensory neurons and these neurons innervate taste buds in fungiform and anterior foliate taste papillae on the surface of the tongue, as well as taste buds in the soft palate. While 35–50% of taste buds on the tongue are innervated by these TH+ neurons, 100% of soft palate taste buds are innervated. These neurons did not have extragemmal processes outside of taste buds and did not express the mechanosensory neuron-associated geneRet, suggesting they are chemosensory and not somatosensory neurons. Within taste buds, TH-expressing fibers contacted both Type II and Type III cells, raising the possibility that they are responsive to more than one taste quality. During this analysis we also identified a rare TH+ taste receptor cell type that was found in only 12–25% of taste buds and co-expressed TRPM5, suggesting it was a Type II cell. Taken together, TH-expressing GG oral sensory neurons innervate taste buds preferentially in the soft palate and contact Type II and Type III taste bud receptor cells.

show abstract

Identification of a population of peripheral sensory neurons that regulates blood pressure

Cited by 19 publications

References 58 publications

The role of somatosensory innervation of adipose tissues

The role of somatosensory innervation of adipose tissues

Is fibromyalgia an autoimmune illness?

Oral Sensory Neurons of the Geniculate Ganglion That Express Tyrosine Hydroxylase Comprise a Subpopulation That Contacts Type II and Type III Taste Bud Cells

Contact Info

Product

Resources

About