Identification of a novel zinc finger gene,zf5-3, as a potential mediator of neuroblastoma differentiation

Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome

“…All TFBS that are found to be statistically significant for FAS are known to be involved in gene expression and regulation in the CNS, endocrine system or development. The AP-2 family of TF is crucial for neural gene expression and neuronal development [ 69 ]; C/EBP is involved in neuronal signalling [ 70 ]; the E2F family of TF is one of the key controllers of cell-cycle and has a known role in pathways controlling neuron death [ 71 ]; ETF, the epidermal growth factor receptor-specific TF, is implicated in neuroblastoma [ 72 ]; LEF1 is expressed in the nerve system of mammals [ 73 ]; MAZ is involved in Hodgkin's disease and paraneoplastic cerebellar dysfunction [ 74 ] and during neuronal differentiation [ 75 ]; MAZR is implicated in the development of mouse limb buds [ 76 ]; MZF1 is involved in development [ 77 ] and implicated in the control of the BACE1 gene related to Alzheimer's disease [ 78 ]; Pax-4 is involved in the endocrine system and development [ 79 ]; Sp1 has multiple roles, but, for example, controls expression of Na+,K+-ATPase in neuronal cells [ 80 ]; Spz1 is involved in cell-proliferation [ 81 ]; TATA binding proteins are implicated in various processes involved in brain [ 82 ]; the TFII-I transcription factor family is implicated in craniofacial development of humans and mice [ 83 ]; VDR is associated with increased risk of schizophrenia [ 84 ]; and ZF5 is implicated in neuroblastoma differentiation [ 85 ]. These results support the prioritization of biologically relevant candidate disease genes.…”

Genetic and Molecular Abnormalities in Tumors of the Bone and Soft Tissues

“…During development of the fetal human brain, high levels of zf5-3 mRNA are restricted to the mitotically active, undif-ferentiated neuroblasts, and morphologic evidence of differentiation is accompanied by a marked loss in zf5-3 expression. 46 Consistent areas of chromosomal loss, including 1p36, 11q23, 14q23,18q21.1 and possibly at 18-q12.3, may identify the location of neuroblastoma suppressor genes. A suppressor gene associated with Nmyc-amplified tumors probably maps to a region that harbors genes such as FGR, SLC9A1, HMG17, EXTL1, AML2, RH, and OP18 with roles in cell growth, differentiation, and morphogenesis.…”