“…Position 7.45 has also been implicated in mGlu 4 and mGlu 5 allosteric modulation (Molck et al, 2012;Gregory et al, 2013bGregory et al, , 2014Turlington et al, 2014;Rovira et al, 2015); there are no reports investigating the influence of this amino acid on selective allosteric modulators of mGlu 1 or mGlu 2 . Between group I mGlu receptors and mGlu 2 , three residues are common: 5.44, 5.47, and 6.55 (Knoflach et al, 2001;Malherbe et al, 2003bMalherbe et al, , 2006Schaffhauser et al, 2003;Hemstapat et al, 2006;Muhlemann et al, 2006;Rowe et al, 2008;Fukuda et al, 2009;Lundstrom et al, 2011;Gregory et al, 2012Gregory et al, , 2013bGregory et al, , 2014Molck et al, 2012). Group 1 receptors and mGlu 4 share a common determinant in F6.51 (Malherbe et al, 2003a(Malherbe et al, ,b, 2006Muhlemann et al, 2006;Suzuki et al, 2007;Fukuda et al, 2009;Gregory et al, 2014;Rovira et al, 2015).…”