“…Recent studies have described several novel genes associated with SLE following WES analysis in an Asian population, such as the decreased expression of cell division cycle 27 (CDC27) in patients ( Shang et al, 2022 ), and novel variants in genes encoding for complement receptor 2 (CR2) ( Tang and Luo, 2022 ), C1R ( Demirkaya et al, 2017 ), NRAS, TNFAIP3 and PIK3CD ( Li et al, 2020 ), WNT16 and ERVW-1 ( Chen et al, 2022 ), ACP5 and SAMHD1 ( Hong et al, 2022 ). This list of genes contributing to monogenic SLE continues to grow with increased usage of WES over the past few years, further enriching our knowledge about the genetic contribution to SLE.…”