Identification of a Novel MicroRNA Panel Associated with Metastasis Following Radical Prostatectomy for Prostate Cancer

Nam, Robert K.; Wallis, Christopher J.D.; Amemiya, Yutaka; Benatar, Tania; Seth, Arun

doi:10.21873/anticanres.12821

Cited by 18 publications

(14 citation statements)

References 52 publications

(70 reference statements)

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“…Previous reports have shown that miR-17-92 cluster were associated with the tumorigenesis in colorectal cancer 31,32 , breast cancer 33 , glioblastoma 34 , skin cancer 35 , gallbladder cancer 36 , hepatocellular cancer 37 , prostate cancer 29 , B-cell lymphoma 30 , and lung cancer 28 . Moreover, it has been reported that high expression level of serum miR-17-3p were correlated with poor prognosis in patients with colorectal cancer 38 and prostate cancer 39 . These reports regarding various types of cancers including lung cancer support our finding that elevated level of serum miR-17-3p highly correlated with lung cancer.…”

Section: Discussionmentioning

confidence: 99%

A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy

Asakura

Kadota

Matsuzaki³

et al. 2020

Commun Biol

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Lung cancer, the leading cause of cancer death worldwide, is most frequently detected through imaging tests. In this study, we investigated serum microRNAs (miRNAs) as a possible early screening tool for resectable lung cancer. First, we used serum samples from participants with and without lung cancer to comprehensively create 2588 miRNAs profiles; next, we established a diagnostic model based on the combined expression levels of two miRNAs (miR-1268b and miR-6075) in the discovery set (208 lung cancer patients and 208 non-cancer participants). The model displayed a sensitivity of 99% and specificity of 99% in the validation set (1358 patients and 1970 non-cancer participants) and exhibited high sensitivity regardless of histological type and pathological TNM stage of the cancer. Moreover, the diagnostic index markedly decreased after lung cancer resection. Thus, the model we developed has the potential to markedly improve screening for resectable lung cancer.

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Section: Discussionmentioning

confidence: 99%

A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy

Asakura

Kadota

Matsuzaki³

et al. 2020

Commun Biol

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“…These are a four-miRNA ratio (miR-23a-3p x miR-10b-5p/miR-133a x miR-374b-5p), named MICaP [95], and a panel based on nine miRNAs, among them miR-185-5p and miR-221-3p, combined with three methylation markers, named miMe [96]. Nam et al [97] introduced a new five-miRNA panel associated with metastasis after RP, while no miRNA was identical with those miRNAs recommended in their preceding report [38]. All these new panels showed promising predictive capacities, but the panels differed and were not compared within the same working group.…”

Section: Discussionmentioning

confidence: 99%

A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature

Zhi

Weickmann

Jung

et al. 2019

Cancers

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Within five to ten years after radical prostatectomy (RP), approximately 15–34% of prostate cancer (PCa) patients experience biochemical recurrence (BCR), which is defined as recurrence of serum levels of prostate-specific antigen >0.2 µg/L, indicating probable cancer recurrence. Models using clinicopathological variables for predicting this risk for patients lack accuracy. There is hope that new molecular biomarkers, like microRNAs (miRNAs), could be potential candidates to improve risk prediction. Therefore, we evaluated the BCR prognostic capability of 20 miRNAs, which were selected by a systematic literature review. MiRNA expressions were measured in formalin-fixed, paraffin-embedded (FFPE) tissue RP samples of 206 PCa patients by RT-qPCR. Univariate and multivariate Cox regression analyses were performed, to assess the independent prognostic potential of miRNAs. Internal validation was performed, using bootstrapping and the split-sample method. Five miRNAs (miR-30c-5p/31-5p/141-3p/148a-3p/miR-221-3p) were finally validated as independent prognostic biomarkers. Their prognostic ability and accuracy were evaluated using C-statistics of the obtained prognostic indices in the Cox regression, time-dependent receiver-operating characteristics, and decision curve analyses. Models of miRNAs, combined with relevant clinicopathological factors, were built. The five-miRNA-panel outperformed clinically established BCR scoring systems, while their combination significantly improved predictive power, based on clinicopathological factors alone. We conclude that this miRNA-based-predictor panel will be worth to be including in future studies.

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“…The role of miRNAs in resistance to treatment for breast cancer is also one of the core issues discussed at present (116). miR-27a also shows potential in the diagnosis/prognosis of prostate cancer and the identification of metastasis after radical prostatectomy (108, 117). In HCC, compared to that of a single AFP marker, the combination of miR-125b/miR-27a/AFP had a higher sensitivity and specificity for the diagnosis of early-stage HCC (109).…”

Section: Mir-27a In Clinical Applicationsmentioning

confidence: 99%

MicroRNA-27a (miR-27a) in Solid Tumors: A Review Based on Mechanisms and Clinical Observations

Zhang

Cao

et al. 2019

Front. Oncol.

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MicroRNAs (miRNAs) are a family of highly conserved, non-coding single-stranded RNAs transcribed as ~70 nucleotide precursors to an 18–22 nucleotide product (1). miRNAs can silence their homologous target genes at the post-transcriptional level, and these genes have been revealed to play an important role in tumorigenesis, invasion and metastasis (2). MicroRNA-27a (miR-27a), transcripted by miR-27a gene, has proved to implicate with many kinds of solid tumors, showing potential as a useful biomarker or drug target for clinical application. However, even though miR-27a has been reported in many cancers, the mechanism and signal pathways of miR-27 in oncogenesis, invasion, and metastasis are still obscure. Moreover, recent studies show that miR-27a pays an important role in epithelial-mesenchymal-transition, regulating tumor immune response, and chemoresistance. In this review, we summarize the current literature, demonstrate the established link between miR-27a and tumorigenesis, and focus on recently identified mechanisms. The review also aims to demonstrate the potential of miR-27a as a diagnostic and/or prognostic biomarker in solid tumors and to discuss the possibilities of targeted therapy and drug design.

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Identification of a Novel MicroRNA Panel Associated with Metastasis Following Radical Prostatectomy for Prostate Cancer

Abstract: A genome-wide analysis of microRNA expression identified a panel of 5 miRNAs strongly associated with prostate cancer metastasis following radical prostatectomy.

Cited by 18 publications

References 52 publications

A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy

A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy

A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature

MicroRNA-27a (miR-27a) in Solid Tumors: A Review Based on Mechanisms and Clinical Observations

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