1997
DOI: 10.1006/geno.1997.5062
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Identification of a Novel HumanRAD51Homolog,RAD51B

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Cited by 114 publications
(55 citation statements)
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“…The proteins maintained at an elevated level in the radiation-derived MCF-7 cells are correlated to cell cycle control, apoptosis, DNA repair, and cell proliferation. The genes responsible for this elevation include: RAD51B, which encodes a DNA repair protein RAD51 homolog 2, which is involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents (28). CCNH encodes cyclin H, which regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex.…”
Section: Discussionmentioning
confidence: 99%
“…The proteins maintained at an elevated level in the radiation-derived MCF-7 cells are correlated to cell cycle control, apoptosis, DNA repair, and cell proliferation. The genes responsible for this elevation include: RAD51B, which encodes a DNA repair protein RAD51 homolog 2, which is involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents (28). CCNH encodes cyclin H, which regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex.…”
Section: Discussionmentioning
confidence: 99%
“…Five paralogs of human RAD51 have been identified: RAD51B (hREC2, RAD51L1), RAD51C (RAD51L2), RAD51D (RAD51L3), XRCC2, and XRCC3; these proteins share ϳ25% amino acid sequence identity with one another and RAD51 (5)(6)(7)(8)(9). DT40 chicken cell knockouts have been generated for each paralog, all of which exhibit a lack of RAD51 foci formation as well as enhanced radiation and cisplatin sensitivity, consistent with a deficiency in recombinational repair (10,11).…”
mentioning
confidence: 87%
“…Evidence has also been presented that RAD51L1 (formerly RAD51B), a member of the RAD51 recombination repair gene family (Albala et al 1997;Shinohara et al 1992), is the chromosome 14 target gene and preferential fusion partner of HMGIC in uterine leiomyomas with t(12;14) (Amant et al 2001;Ingraham et al 1999;Schoenmakers et al 1999;Takahashi et al 2001). Although the RAD51L1 protein has not yet been shown to catalyze recombination reactions, RAD51L1 appears to be an essential gene (Shu et al 1999) expressed in almost all organs and tissues (Rice et al 1997) and probably plays a role in regulation of cell cycle progression (Havre et al 1998(Havre et al , 2000.…”
Section: The Genetic Findingsmentioning
confidence: 99%