Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia

Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance

“…Alternatively, an abnormal total number of chromosomes results in non-specific genetic imbalance, which may also induce enhanced apoptosis at the early stage of neural stem cell differentiation. This study suggests that autosomal imbalance triggers apoptosis during early neuronal differentiation by altering the expression of a set of genes, which were identified as a common cluster and reported to be involved in cell proliferation, as well as neurite outgrowth and differentiation [11][12][13][14][15][16][17][18]. We suggest that dysregulation of these genes leads to excess apoptosis during early neurogenesis by altering the cell cycle progression and differentiation program.…”

Proteomics analysis of component in serum with anti-asthma activity derived from rats treated by acupuncture

“…Zinc finger protein family has close relationship with the regulation of gene expression. Zinc finger protein 91 relates to cell proliferation, and anti-apoptosis [27] . The activity of zinc finger protein 208 is still unclear.…”

An Atypical E3 Ligase Zinc Finger Protein 91 Stabilizes and Activates NF-κB-inducing Kinase via Lys63-linked Ubiquitination

“…In this study, a cDNA microarray analysis with a diterpenoid kamebakaurin, which specifically inhibits DNA binding by the p50 subunit of NF-B complex (16), revealed a novel gene, ZFP91 (zinc finger protein 91), which has consecutive zinc finger (ZnF) domains and is known to be highly expressed in most human acute myelogenous leukemia cases (17). We here demonstrate that ZFP91 is an atypical E3 ligase activating NIK via Lys 63 -linked ubiquitination in the noncanonical NF-B signaling pathway.…”