Identification of a novel HLA‐DRB1 allele (DRB1*1147)* by sequence‐based typing in eight siblings

Abstract

We report here a novel DRB1 allele (DRB1*1147) identified by sequence-based typing. The DRB1*1147 allele was detected during routine human leukocyte antigen (HLA)-typing of a patient and his family prior to bone marrow transplantation. This allele was found in the patient and his two sisters and five brothers. The new allele is identical to DRB1*110601 at exon 2 except for a single-nucleotide substitution at codon 37 (TAC-->TCC), changing the encoded tyrosine to serine.

Identification of a novel HLA‐DRB1 allele (HLA‐DRB1*111902*)

“…HLA‐DRB1 allele is the most polymorphic HLA class II locus, and the highest variation of HLA‐DRB1 allele is located in the exon 2 of the gene. With the application of DNA‐based HLA‐typing technology, several new HLA‐DRB1 alleles have been identified in China (2, 3).…”