Identification of a novel gene set in human cumulus cells predictive of an oocyte's pregnancy potential

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

“…In addition, cumulus cell gene expression of HAS2 and FSH receptor has been used to select up to three metaphase II oocytes within a cohort of oocytes, from which one selected oocyte (vs. a randomly selected metaphase II oocyte) has a 60% (vs. a 38%) chance of developing to a live birth (111). Similarly, human cumulus cell expression of 12 genes involving glucose metabolism, transcription, gonadotropin regulation, and apoptosis appears to predict pregnancy outcome with 78% accuracy (117). To date, however, there is no consensus as to which genes are the most useful as biomarkers of oocyte competence, perhaps because oocyte mRNA and protein expression poorly correlate with each other owing to previous synthesis/storage of transcripts in the oocyte for later translation (118).…”

Metabolism alteration in follicular niche: The nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome

“…In addition, CCs are considered to be an important biological marker of oocyte developmental potential [17].…”

No Specific Gene Expression Signature in Human Granulosa and Cumulus Cells for Prediction of Oocyte Fertilisation and Embryo Implantation

“…In recent years, several studies have tried to identify candidate genes expressed in somatic cells of ovarian follicles that could be used as biomarkers of oocyte and embryo quality [10,11] and successful embryo implantation [12,13,14,15]. However, the genes proposed as potential biomarkers show little overlap between different study groups.…”