Identification of a novel common proviral integration site, flit-1, in feline leukemia virus induced thymic lymphoma

Fujino, Yasuhito; Liao, Chun-Peng; Zhao, Yan; Pan, Judong; Mathes, Lawrence E.; Hayes, Kathleen; Ohno, Koichi; Tsujimoto, Hajime; Roy-Burman, Pradip

doi:10.1016/j.virol.2009.01.021

Cited by 10 publications

(8 citation statements)

References 42 publications

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“…Among 35 FeLV-related tumors, five of 25 thymic lymphomas demonstrated proviral insertion within flit-1 locus, whereas none of four alimentary, five multicentric lymphomas, and one T-lymphoid leukemia examined had rearrangement in this region. Expression of ACVRL1 mRNA was detected the two thymic lymphomas with flit-1 rearrangement, whereas normal thymuses and seven lymphoid tumors without flit-1 rearrangement had no detectable ACVRL1 mRNA expression (Fujino et al, 2009).…”

Section: Feline Leukemia Virus Infectionmentioning

confidence: 90%

Clinical aspects of feline immunodeficiency and feline leukemia virus infection

Hartmann¹

2011

Veterinary Immunology and Immunopathology

152

155

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Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with a global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FIV can cause an acquired immunodeficiency syndrome that increases the risk of developing opportunistic infections, neurological diseases, and tumors. In most naturally infected cats, however, FIV itself does not cause severe clinical signs, and FIV-infected cats may live many years without any health problems. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cats. FeLV can cause tumors (mainly lymphoma), bone marrow suppression syndromes (mainly anemia) and lead to secondary infectious diseases caused by suppressive effects of the virus on bone marrow and the immune system. Today, FeLV is less important as a deadly infectious agent as in the last 20 years prevalence has been decreasing in most countries.

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Section: Feline Leukemia Virus Infectionmentioning

confidence: 90%

Clinical aspects of feline immunodeficiency and feline leukemia virus infection

Hartmann¹

2011

Veterinary Immunology and Immunopathology

152

155

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“…Among 35 FeLV-related tumors, 5/25 thymic lymphomas demonstrated proviral insertion within flit-1 locus, whereas 0/4 alimentary lymphomas, 5/5 multicentric lymphomas, and 1/1 T-lymphoid leukemia examined had rearrangements in this region. Expression of ACVRL1 mRNA was detected in the two thymic lymphomas with flit-1 rearrangement, whereas normal thymuses and seven lymphoid tumors without flit-1 rearrangement had no detectable ACVRL1 mRNA expression [51]. …”

Section: Clinical Signsmentioning

confidence: 99%

“…Lymphopenia is caused by direct replication of the virus in CD4 + lymphocytes. Anemia and neutropenia (usually mild) may also be seen [4,51], although these abnormalities may be as much a reflection of concurrent disease as direct effects of FIV itself. A recent study in a high number (3784) of client-owned field cats compared hematologic parameters in FIV-infected, FeLV-infected and uninfected cats [4].…”

Section: Clinical Signsmentioning

confidence: 99%

“…Only neutropenia was significantly more often present, in about 25% of FIV-infected cats. Soluble factors have been shown to inhibit bone marrow function in FIV-infected cats, and bone marrow infection has been associated with decreased ability to support hematopoietic potential in vitro or has been proposed as a mechanism underlying the development of cytopenias [51]. …”

Section: Clinical Signsmentioning

confidence: 99%

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Clinical Aspects of Feline Retroviruses: A Review

Hartmann¹

2012

Viruses

274

301

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Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cats. FeLV can cause tumors (mainly lymphoma), bone marrow suppression syndromes (mainly anemia), and lead to secondary infectious diseases caused by suppressive effects of the virus on bone marrow and the immune system. Today, FeLV is less commonly diagnosed than in the previous 20 years; prevalence has been decreasing in most countries. However, FeLV importance may be underestimated as it has been shown that regressively infected cats (that are negative in routinely used FeLV tests) also can develop clinical signs. FIV can cause an acquired immunodeficiency syndrome that increases the risk of opportunistic infections, neurological diseases, and tumors. In most naturally infected cats, however, FIV itself does not cause severe clinical signs, and FIV-infected cats may live many years without any health problems. This article provides a review of clinical syndromes in progressively and regressively FeLV-infected cats as well as in FIV-infected cats.

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“…Most cytoproliferative diseases are attributed to insertional mutagenesis, a process by which FeLV DNA integrates at a site in the cat’s genome that disrupts or deregulates expression of proteins involved in the regulation of cell cycle, cell survival, or apoptosis 27–32. In contrast, FeLV plays an indirect role in the formation of feline fibrosarcoma.…”

Section: Pathobiologymentioning

confidence: 99%

Broadening the use of antiretroviral therapy: the case for feline leukemia virus

Greggs¹,

Clouser²,

Patterson³

et al. 2011

TCRM

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Antiretroviral drugs have saved and extended the lives of millions of individuals infected with HIV. The major classes of anti-HIV drugs include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry/fusion inhibitors. While antiretroviral drug regimens are not commonly used to treat other types of retroviral infections, there are instances where there is a perceived need for re-evaluation of the benefits of antiretroviral therapy. One case in point is that of feline leukemia virus (FeLV), an infection of companion felines. While vaccines exist to prevent FeLV infection and spread, they have not eliminated FeLV infection. For FeLV-infected felines and their human companions, antiretroviral therapy would be desirable and of practical importance if good options were available. Here, we discuss FeLV biology and current treatment options, and propose that there is a need for antiretroviral treatment options for FeLV infection. The comparative use and analysis of antiretroviral therapy can provide new insights into the mechanism of antiretroviral drug action.

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Identification of a novel common proviral integration site, flit-1, in feline leukemia virus induced thymic lymphoma

Cited by 10 publications

References 42 publications

Clinical aspects of feline immunodeficiency and feline leukemia virus infection

Clinical aspects of feline immunodeficiency and feline leukemia virus infection

Clinical Aspects of Feline Retroviruses: A Review

Broadening the use of antiretroviral therapy: the case for feline leukemia virus

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