Identification of a new allele, HLA‐DRB1*1360, on a DRB5 haplotype in a Brazilian individual

Abstract

The application of DNA-based methods for human leukocyte antigen (HLA) genotyping has revealed an ever-increasing degree of polymorphism within the HLA-DRB loci and has resulted in the discovery of new alleles. We have identified a new DRB1 allele that was subsequently named DRB1*1360 by the WHO Nomenclature Committee. This allele is unusual for a DRB1*13 allele, as it is present on a DRB5 haplotype rather than the normal DRB3 haplotype found in association with DRB1*13 alleles.

Polimorfismo do HLA de classe II em populações brasileiras

“…Of the total number of articles, nine didn't fit in the objectives of the present study (BELICH et al, 1992;BLACK et al, 1980;FERNANDEZ-VINA et al, 1991a;FERNANDEZ-VINA et al, 1991b;FERNANDEZ-VINA et al, 1997;GOLD-BERG et al, 1998;MORAES et al, 2004;SOARES-VIEIRA et al, 1999;TESTA et al, 2004;TRACHTENBERG et al, 1988). In three of them the focus was the HLA class I molecules (BELICH et al, 1992;BLACK et al, 1980;TRACHTENBERG et al, 1988), six articles, although studying HLA class II antigens, did not specified the ethnic origin of the individuals or separated the results according to race/ethnicity (FERNANDEZ-VINA et al, 1991a;FERNANDEZ-VINA et al, 1991b;FERNANDEZ-VINA et al, 1997;GOLD-BERG et al, 1998;MORAES et al 2004;TESTA et al, 2004).…”

“…We found twenty-four articles published between 1980 and 2004 about HLA and Brazilian populations (BELICH et al, 1992;BLACK et al, 1980;CERNA et al, 1993;DONADI;SILVA, 2000;ERLICH et al, 1997;FERNANDEZ-VINA et al, 1991a;FER-NANDEZ-VINA et al, 1991b;FER-NANDEZ-VINA et al, 1997;GOLDBERG et al, 1998;LÁZARO et al, 1999;LOUZADA-JUNIOR et al, 2001;MACIAG et al, 2000;MACK;ERLICH, 1998;MORAES et al, 1993;MORAES et al, 2004;PANDO et al, 1994;PETZL-ERLER et al, 1993;PETZL-ERLER;MCDEVITT, 1994;PROBST et al, 2000;SOARES-VIEIRA et al, 1999;SOTOMAIOR et al, 1998;TESTA et al, 2004;TRACHTENBERG et al, 1988;TSUNETO et al, 2003). Of the total number of articles, nine didn't fit in the objectives of the present study (BELICH et al, 1992;BLACK et al, 1980;FERNANDEZ-VINA et al, 1991a;FERNANDEZ-VINA et al, 1991b;FERNANDEZ-VINA et al, 1997;GOLD-BERG et al, 1998;MORAES et al, 2004;SOARES-VIEIRA et al, 1999;TESTA et al, 2004;TRACHTENBERG et al, 1988). In three of them the focus was the HLA class I molecules (BELICH et al, 1...…”