Identification of a low risk subgroup of stage IB lung adenocarcinoma patients

Blood Vessel Invasion as a Strong Independent Prognostic Indicator in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

“…In all, according to the positivity for BVI as defined by the authors, 29.8% of tumors harbored BVI by cancer cells (median; range from 6.2% to 77.0%). A total of 47 studies dealt with all types of NSCLC, four with adenocarcinoma alone [14], [27], [38], [41] and one with squamous cell carcinoma alone [39]. A total of 23 studies dealt with only stage I patients.…”

“…In univariate analysis, 33 studies identified blood vessels as a significant prognostic factor for OS [8], [9], [12], [20]–[25], [27]–[34], [43]–[47], [58], [16], [17], [35], [37]–[42], [59], and seven identified it as not significant for survival [18], [50], [52]–[55], [70]. In multivariate analyses, there were 27 studies that identified BVI as a significant prognostic factor for OS [8]–[10], [16], [20], [23], [26], [27], [31]–[47], [58], [59] and 10 that identified blood vessel as a non-significant prognostic factor [18], [21], [28], [30], [48], [49], [52], [53], [56], [70].…”

“…Some studies reported the HR but did provide sufficient information on survival by BVI status; we thus estimated the HR and CIs according to the methods of Parmar et al [61]. As shown in Table S1, the total number of events [53], the log-rank statistic or its P value [9]–[12], [14], [17], [18], [20]–[22], [25], [27], [28], [34], [35], [39]–[42], [44], [46], [47], [50], [51], [54], [57], [58], or data from Kaplan-Meier survival curves [16]–[19], [59] were used to allow an approximate calculation of the HR. Heterogeneity was tested with the χ 2 -based Q test [62].…”

Impact of visceral pleural invasion on the survival of patients with non-small cell lung cancer

“…between IA and IB disease and that lymphatic invasion and vessel invasion have less impact on prognosis than VPI, suggesting that pleural lymphatic drainage is a more efficient pathway for metastasis [21]. The other reason is the rapidity with which a lung cancer in a subpleural location invades the pleura and disseminates cancer cells throughout the pleural cavity.…”

Prognostic factors of patients with pathologic stage I lung adenocarcinoma

“…There is a close relationship between histology appearances and gene mutations. Other predictors for pathologic stage I lung adenocarcinoma are clinicopathologic parameters, such as tumor size (4,16), TNM stage (4,13), aerogenous spread (5,9), tumor differentiation (4), bronchial involvement (4), lymphovascular invasion (4,18,23,26), positive thyroid transcription factor-1 (TTF-1) expression (19,28), lepidic growth pattern (16), sex (16), age (22), tumor budding (14), pleural invasion (29), carcinoembryonic antigen levels (30), and standardized uptake value (SUV) index (<1.0) (25).…”