1999
DOI: 10.1292/jvms.61.1261
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Identification of a Locus for Susceptibility to Renal Cell Carcinoma in the Long-Evans Cinnamon Rat

Abstract: ABSTRACT. The Long-Evans Cinnamon (LEC) mutant rat shows higher incidence of renal cell carcinomas induced by a treatment with the chemical carcinogen N-diethylnitrosamine, as compared to the normal control rat. We performed the first genome-wide scan for genes responsible for susceptibility to chemically induced renal cell carcinoma in an F 2 intercross obtained by mating the LEC and Fischer-344 (F344) rats. The genotype of 71 (F344 × LEC) F 2 progenies was determined with the use of 338 simple sequence lengt… Show more

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References 27 publications
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