Identification of a human cartilage microbiome and characterization of distinct microbiome profiles associated with osteoarthritis

Dunn, Christopher M.; Velasco, C.; Rivas, Alexander; Jacob, Paul; Jeffries, Matlock A.

doi:10.1016/j.joca.2018.02.378

Cited by 6 publications

(11 citation statements)

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“…The finding of gut microbiota in all samples of human cartilage studied by Dunn et al , 23 which differed according to joints, would imply that the presence of those bacteria in cartilage is not random, and could play a physiological role, despite their very low numbers and steady state. For instance, their ability to transform some components of deep cartilage matrix in metabolites with immunosuppressive properties might be one reason for their unexpected presence close to cartilage.…”

Section: Could Gut Microbiota Have a Physiological Role In Normal Submentioning

confidence: 94%

“…Using sterile procedure, cartilage was obtained from primary OA knee and hip replacements, and in each location both OA-eroded and preserved cartilages were gathered 23. Cartilage of patients free from OA was obtained from 30 fresh cadavers of similar sexes, age and body mass index (BMI).…”

Section: Gut Microbiome Was Recently Found In Human Cartilagementioning

confidence: 99%

“…Hip OA microbiota was dominated by the phylum Proteobacteria, whereas knee OA microbiota was characterised by Actinobacteria. Similarly, 46 differences were seen in knee controls versus hip controls 23. A study in OA shoulder concluded to the opposite since after stringent removal of contamination, only genomic DNA from various Acinetobacter spp and from the Oxalobacteraceae family could be identified in 74% of rotator cuff tendon tissue samples, but not in humeral head cartilage 24.…”

Section: Gut Microbiome Was Recently Found In Human Cartilagementioning

confidence: 99%

“…It has not yet been studied whether this DNA was stored within the subchondral bone marrow, deep cartilage vessels, cartilage matrix or chondrocytes themselves 23. How this DNA (and perhaps still living bacteria from microbiota) reaches cartilage remains unclear.…”

Section: How Microbiota Dna or Gut Bacteria Could Reach The Cartilagementioning

confidence: 99%

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Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis

Berthelot¹,

Sellam

Maugars³

et al. 2019

RMD Open

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DNA of gut microbiota can be found in synovium of osteoarthritis and rheumatoid arthritis. This finding could result from the translocation of still alive bacteria from gut to joints through blood, since the diversified dormant microbiota of healthy human blood can be transiently resuscitated in vitro. The recent finding of gut microbiome in human cartilage, which differed between osteoarthritis and controls, suggests that a similar trafficking of dead or alive bacteria from gut microbiota physiologically occurs between gut and epiphysial bone marrow. Subchondral microbiota could enhance cartilage healing and transform components of deep cartilage matrix in metabolites with immunosuppressive properties. The differences of microbiome observed between hip and knee cartilage, either in osteoarthritis or controls, might be the counterpart of subtle differences in chondrocyte metabolism, themselves in line with differences in DNA methylation according to joints. Although bacteria theoretically cannot reach chondrocytes from the surface of intact cartilage, some bacteria enter the vascular channels of the epiphysial growth cartilage in young animals, whereas others can infect chondrocytes in vitro. In osteoarthritis, the early osteochondral plate angiogenesis may further enhance the ability of microbiota to locate close to the deeper layers of cartilage, and this might lead to focal dysbiosis, low-grade inflammation, cartilage degradation, epigenetic changes in chondrocytes and worsening of osteoarthritis. More studies on cartilage across different ethnic groups, weights, and according to age, are needed, to confirm the silent presence of gut microbiota close to human cartilage and better understand its physiologic and pathogenic significance.

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Section: Could Gut Microbiota Have a Physiological Role In Normal Submentioning

confidence: 94%

Section: Gut Microbiome Was Recently Found In Human Cartilagementioning

confidence: 99%

Section: Gut Microbiome Was Recently Found In Human Cartilagementioning

confidence: 99%

Section: How Microbiota Dna or Gut Bacteria Could Reach The Cartilagementioning

confidence: 99%

See 2 more Smart Citations

Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis

Berthelot¹,

Sellam

Maugars³

et al. 2019

RMD Open

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“…Increasingly, research reports indicate an important role of the gastrointestinal milieu in health and a wide range of conditions, from chronic kidney disease (45) to allergies (60) and diseases of connective tissue (61). Recent advances have also expanded understanding of the possible role of the gut ecological environment on pain signaling and peripheral sensitisation (62), and identifying commensal gut bacteria at sub-infective levels in synovial fluid (63) and joint cartilage (64) adds credence to what currently is a hypothetical gut microbiota -musculoskeletal interaction (65). While we did not seek to explore FGIDs in other rheumatic or musculoskeletal conditions, these groups are often used in comparison to fibromyalgia.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of the association between fibromyalgia and functional gastrointestinal disorders

Erdrich¹

2020

Preprint

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Background Fibromyalgia and functional gastrointestinal disorders are frequently encountered in clinical settings. Common to both is significant burden on individuals and health care systems, an elusive aetiology and several comorbid conditions. While a relationship between irritable bowel syndrome and fibromyalgia has been demonstrated, a broader review of the relationship between fibromyalgia and other functional gut disorders has not been undertaken. Objectives This paper reports a systematic review of the published literature, identifying the comorbidity of functional gastrointestinal disorders in people with fibromyalgia. We discuss the clinical implications, limitations of current research, and areas of interest for future research Methods A systematic review of the databases Medline, Embase, CINAHL and Web of Science was undertaken in June 2019. Results were screened for original articles meeting strict criteria for identification of functional gastrointestinal disorders in adult subjects with fibromyalgia. ResultsFourteen articles were included investigating 1340 subjects with fibromyalgia, 363 healthy controls and 441 subjects with other pathologies. Functional gut disorders were matched to Rome II criteria for reporting and comparison. In addition to increased abdominal pain and functional bloating/gas, irritable bowel of mixed-pattern and constipation-types were more prevalent that diarrhoea-predominant irritable bowel in adults with fibromyalgia. One study reported the range of functional gastrointestinal disorders. Conclusion Existing research has focused on the relationship between irritable bowel syndrome and fibromyalgia, but sub-typing of irritable bowel syndrome is generally overlooked. A strong association with a range of functional gastrointestinal disorders is suggested. Further investigation is needed to determine the prevalence and relevance of the range of functional gastrointestinal disorders in patients with fibromyalgia.

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The causal role of gut microbiota in development of osteoarthritis

Yang

Cao

et al. 2021

Osteoarthritis and Cartilage

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Identification of a human cartilage microbiome and characterization of distinct microbiome profiles associated with osteoarthritis

Cited by 6 publications

References 0 publications

Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis

Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis

A systematic review of the association between fibromyalgia and functional gastrointestinal disorders

The causal role of gut microbiota in development of osteoarthritis

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