Abstract:Background and Purpose: 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1)
catalyzes the oxoreduction of cortisone to cortisol, thereby amplifying
levels of active glucocorticoids. It is considered a pharmaceutical
target in metabolic disease and cognitive impairments. 11β-HSD1 also
converts some 7oxo-steroids to their 7β-hydroxy forms. A recent study in
mice described the ratio of tauroursodeoxycholic acid
(TUDCA)/tauro-7oxolithocholic acid (T7oxoLCA) as a biomarker for
decreased 11β-HSD1 oxoreductase activity. Th… Show more
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