Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation

Boulard, Olivier; Kirchberger, Stefanie; Royston, Daniel; Maloy, Kevin J.; Powrie, Fiona

doi:10.1084/jem.20120239

Cited by 45 publications

(55 citation statements)

References 56 publications

(93 reference statements)

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“…In tissue, the IL-17 and IL-22 pathways were robustly induced (GM-CSF, IFN-γ, IL-6, IL-1β, KC, TNF-α). In the Rag2 −/− mouse these expression patterns point to phagocytes, innate lymphoid cells, or epithelial cells as possible sources (44)(45)(46)(47). Furthermore, the signals strongly connect neutrophils to the site of inflammation, confirming the previous demonstration based on histological evaluation (10).…”

Section: Quantitative Pcr Array-based Transcript Profiling Of Inflammsupporting

confidence: 82%

Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease

Knutson

Mangerich

Zeng

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

103

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Significance Our study investigates chemical damage associated with chronic inflammation and relates these macromolecular damage products to inflammatory bowel disease activity. Using mice as a model system, we show that chronic inflammatory responses that are common to mice and humans produce similar types and quantities of damage products in both species. Additional analysis of signaling molecules in the serum and tissue of diseased samples highlights the role of the innate immune response in the overall pathology of inflammatory bowel disease.

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Section: Quantitative Pcr Array-based Transcript Profiling Of Inflammsupporting

confidence: 82%

Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease

Knutson

Mangerich

Zeng

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

103

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“…With this Hiccs interval protection from H. hepaticus infection, innate immune responses of certain proinflammatory cytokines such as TNF, IL-1β, and INF-γ, were dampened[75]. This finding further confirms that some microRNAs are genetically destined to control inflammatory mediators.…”

Section: Introductionmentioning

confidence: 63%

How microRNAs influence both hereditary and inflammatory-mediated colon cancers

et al. 2013

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MicroRNAs have emerged as important post-translational regulators of gene expression and are involved in several physiological and pathological states including the pathogenesis of human colon cancers. In regards to tumor development, microRNAs can act as oncogenes or tumor suppressors. Both hereditary predispositions (i.e. Lynch Syndrome and Familial Adenomatous Polyposis) contribute to the development of colon cancer. In addition, individuals who suffer from inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis have a higher risk of developing colon cancer. Here, we discuss the occurrence of the deregulated expression of miRNAs in colon cancer that arise due to hereditary predisposition and inflammatory bowel disease.

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“…Additionally, IL-22 keeps pathogenic microbiota at bay and its deficiency increases colitis 53 . Moreover, it has been shown that IL-22 can induce chemokines and various anti-bacterial peptides 51, 52, 54, 55 . In summary, IL-22 functions in maintaining the integrity of the epithelial barrier 51 , on the other hand, IL-22 is required for colitis development driven by Helicobacter in Rag -/- mice 55 .…”

Section: Intestinal Inflammation and Tumor Microenvironment: Differenmentioning

confidence: 99%

Cytokines, IBD, and Colitis-associated Cancer

Francescone

Hou

Grivennikov

2015

Inflammatory Bowel Diseases

239

197

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Inflammatory bowel diseases (IBDs) are debilitating conditions that result in intestinal damage due to chronic inflammation. In addition, the perpetual state of inflammation predisposes individuals to the development of colitis associated cancer (CAC). Because of the immense immune cell infiltration into colon, cytokines produced by immune cells are major players in the initiation and progression of IBD and CAC. In this review, we will explore the functions of many key cytokines and their roles in IBD and CAC, as well as their influences on the immune system and stromal cells. Finally, we will briefly discuss current therapies and current clinical trials targeting cytokines in IBD.

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Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation

Abstract: A genetic locus acting in hematopoietic cells regulates cytokine expression and granulocyte recruitment to confer susceptibility in a Helicobacter hepaticus–induced model of innate colitis and associated cancer.

Cited by 45 publications

References 56 publications

Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease

Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease

How microRNAs influence both hereditary and inflammatory-mediated colon cancers

Cytokines, IBD, and Colitis-associated Cancer

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