Identification of a gene expression signature associated with brain metastasis in colorectal cancer
Marlies Michl,
Francesco Taverna,
Christine Woischke
et al.
Abstract:Purpose
Brain metastasis (BM) in colorectal cancer (CRC) is a rare event with poor prognosis. Apart from (K)RAS status and lung and bone metastasis no biomarkers exist to identify patients at risk. This study aimed to identify a gene expression signature associated with colorectal BM.
Methods
Three patient groups were formed: 1. CRC with brain metastasis (BRA), 2. exclusive liver metastasis (HEP) and, 3. non-metastatic disease (M0). RNA was extracted from … Show more
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