Identification of a four-microRNA panel in serum for screening renal cell carcinoma

Chen, Xuan; Li, Rongkang; Li, Xinji; Peng, Xiqi; Zhang, Chunduo; Liu, Kaihao; Huang, Guoxin; Lai, Yongqing

doi:10.1016/j.prp.2021.153625

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…Thus, miR-21 expression alone in primary tumors seems of limited interest as a diagnostic or a prognostic biomarker, and should rather be included in miRNA signature [ 86 , 87 , 88 , 89 ]. Furthermore, miR-21 is also detected in RCC patient serums, and could be used as biomarker but only in combination with other miRNAs, such as miR-106a, miR-310-3p, miR-150-5p and miR-145-5p [ 90 , 91 , 92 ]. cRCC accounts for 70–85% of all RCC cases, and is typically highly resistant to conventional therapies [ 93 , 94 ].…”

Section: Mir-21 In Kidney Injuries and Diseasesmentioning

confidence: 99%

The Versatile Role of miR-21 in Renal Homeostasis and Diseases

Larrue

Fellah

Hauwaert

et al. 2022

Cells

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MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset and progression of various forms of acute and chronic renal disorders. In recent years, miR-21, one of the best-characterized miRNAs to date, has received much attention in renal physiology in particular given its high degree of conservation and expression in kidneys, as well as its potent pathogenic role in various debilitating renal diseases. This review summarizes the current knowledge on miR-21’s involvement in both renal homeostasis and diseases, in particular its double-edged-sword role in acute versus chronic kidney injuries. Finally, we also discuss the potential of miR-21 as a biomarker and therapeutic target in renal diseases.

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Section: Mir-21 In Kidney Injuries and Diseasesmentioning

confidence: 99%

The Versatile Role of miR-21 in Renal Homeostasis and Diseases

Larrue

Fellah

Hauwaert

et al. 2022

Cells

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“…Upregulation of miR-150-5p was observed in NSCLC tissue and cell lines; miR-150-5p promoted proliferation and migration of lung cancer cells, as well as suppressed their apoptosis [ 49 ]. The serum level of miR-150-5p was significantly higher in patients of renal cell carcinoma than healthy control subjects [ 50 ]. However, many other studies reported the tumor suppressive effects of miR-150-5p.…”

Section: Discussionmentioning

confidence: 99%

miR-150-5p-Containing Extracellular Vesicles Are a New Immunoregulator That Favor the Progression of Lung Cancer in Hypoxic Microenvironments by Altering the Phenotype of NK Cells

Chang

Tsai

Hung

et al. 2021

Cancers

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Natural killer (NKs) cells are cytotoxic effector cells, which can modulate tumor metastasis according to their function; however, the role of NK cells in lung cancer has not been extensively investigated. In this study, we determined the functional profiles of NK cells in a hypoxic tumor microenvironment (TME) of lung cancer. We revealed CD226 downregulation and functional repression of NK cells after hypoxic lung cancer priming and we then investigated their interaction with extracellular vesicles (EVs) and miR-150-5p. We also found that NK cells from lung cancer patients had lower expression of CD226 on their surface and exhibited a pro-inflammatory, pro-angiogenic and tumorigenesis phenotype by expressing VEGF, CXCL1, CXCL8, S100A8 and MMPs. Moreover, inhibition of miR-150 improved tumor surveillance by reversing CD226 expression and subsequently reinstating cytotoxic NK cell activity in an animal model. Our study introduces a new scenario for the pro-inflammatory and pro-angiogenic activities of NK cells in the hypoxic TME in lung cancer.

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“…A few clinical trials have tested miRNA for RCC detection. Chen et al used a panel of miR-21-5p, miR-150-5p, miR-145-5p, and miR-146a-5p, showing an AUC of 0.938 [131]. miR-21-5p, hypothesized to play a role in the epithelial mesenchymal transition, was also used as part of a four-miRNA urine panel, with a sensitivity of about 83% [132,133].…”

Section: The Value Of Evs In Kidney Cancer Detection and Diagnosismentioning

confidence: 99%

Clinical Significance of Extracellular Vesicles in Prostate and Renal Cancer

Chen,

Mihalopoulos,

Zuluaga

et al. 2023

IJMS

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Extracellular vesicles (EVs)—including apoptotic bodies, microvesicles, and exosomes—are released by almost all cell types and contain molecular footprints from their cell of origin, including lipids, proteins, metabolites, RNA, and DNA. They have been successfully isolated from blood, urine, semen, and other body fluids. In this review, we discuss the current understanding of the predictive value of EVs in prostate and renal cancer. We also describe the findings supporting the use of EVs from liquid biopsies in stratifying high-risk prostate/kidney cancer and advanced disease, such as castration-resistant (CRPC) and neuroendocrine prostate cancer (NEPC) as well as metastatic renal cell carcinoma (RCC). Assays based on EVs isolated from urine and blood have the potential to serve as highly sensitive diagnostic studies as well as predictive measures of tumor recurrence in patients with prostate and renal cancers. Overall, we discuss the biogenesis, isolation, liquid-biopsy, and therapeutic applications of EVs in CRPC, NEPC, and RCC.

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Identification of a four-microRNA panel in serum for screening renal cell carcinoma

Cited by 12 publications

References 23 publications

The Versatile Role of miR-21 in Renal Homeostasis and Diseases

The Versatile Role of miR-21 in Renal Homeostasis and Diseases

miR-150-5p-Containing Extracellular Vesicles Are a New Immunoregulator That Favor the Progression of Lung Cancer in Hypoxic Microenvironments by Altering the Phenotype of NK Cells

Clinical Significance of Extracellular Vesicles in Prostate and Renal Cancer

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