Identification of a fish specific chemokine CXCL_F2 in large yellow croaker ( Larimichthys crocea ) reveals its primitive chemotactic function

Zhou, Shimin; Mu, Yinnan; Liu, Yingdi; Ao, Jingqun; Chen, Xinhua

doi:10.1016/j.fsi.2016.10.012

Cited by 16 publications

(1 citation statement)

References 34 publications

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“…Macrophage mannose receptors bind high-mannose containing structures on the surface of potentially pathogenic bacteria, viruses, and fungi, thus facilitating the neutralization of these pathogens by phagocytic engulfment 35 . CCL2, CCL3, and CCL5 belonging to inflammatory chemokines, are produced in high concentrations during infection or injury and determine the migration of inflammatory leukocytes into the damaged area [36][37][38][39][40] . All these gene expansions therefore provide new insights into the mechanisms underlying the adaptation of this species to diverse environmental conditions.…”

Section: Discussionmentioning

confidence: 99%

An improved genome assembly for Larimichthys crocea reveals hepcidin gene expansion with diversified regulation and function

Huo

Guan

et al. 2019

Fish & Shellfish Immunology

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Larimichthys crocea (large yellow croaker) is a type of perciform fish well known for its peculiar physiological properties and economic value. Here, we constructed an improved version of the L. crocea genome assembly, which contained 26,100 protein-coding genes. Twenty-four pseudo-chromosomes of L. crocea were also reconstructed, comprising 90% of the genome assembly. This improved assembly revealed several expansions in gene families associated with olfactory detection, detoxification, and innate immunity. Specifically, six hepcidin genes (LcHamps) were identified in L. crocea, possibly resulting from lineage-specific gene duplication. All LcHamps possessed similar genomic structures and functional domains, but varied substantially with respect to expression pattern, transcriptional regulation, and biological function. LcHamp1 was associated specifically with iron metabolism, while LcHamp2s were functionally diverse, involving in antibacterial activity, antiviral activity, and regulation of intracellular iron metabolism. This functional diversity among gene copies may have allowed L. crocea to adapt to diverse environmental conditions.

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