Identification of a distinct cluster of GDF15highmacrophages exhibiting anti-inflammatory activities
Chaochao Dai,
Hongyu Zhang,
Zhijian Zheng
et al.
Abstract:Macrophage-mediated inflammatory response may have crucial roles in the pathogenesis of a variety of human diseases. Growth differentiation factor 15 (GDF15) is a cytokine of the transforming growth factor-β superfamily, with potential anti-inflammatory activities. Previous studies observed in human lungs some macrophages which expressed a high level of GDF15. In the present study, we employed multiple techniques, including immunofluorescence, flow cytometry, and single-cell RNA sequencing, in order to further… Show more
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